5-Fluoro-2-Nitrophenol Sigma Aldrich Alternative | CAS 446-36-6
Validating CAS 446-36-6 Identity Against Thermo Fisher A12568.18 Specifications
When transitioning supply chains for critical intermediates like 5-Fluoro-2-nitrophenol, identity validation is the primary checkpoint for R&D continuity. The chemical identity is anchored by CAS 446-36-6, corresponding to the IUPAC name 5-fluoro-2-nitrophenol. Based on authoritative data from PubChem (CID 9937), the molecular formula is strictly defined as C6H4FNO3 with a molecular weight of 157.10 g/mol. These fundamental constants do not vary between suppliers, but the verification process ensures that the material received matches the theoretical structure required for downstream synthesis.
Procurement managers often reference catalog numbers such as Thermo Fisher A12568.18 to establish a baseline for purity expectations, typically noted at 98%. However, relying solely on catalog specifications without batch-specific verification can introduce risk during scale-up production. At NINGBO INNO PHARMCHEM CO.,LTD., we emphasize the importance of cross-referencing the Certificate of Analysis (COA) against these standard identifiers. The structural integrity of the Fluoronitrophenol derivative must be confirmed via NMR or HPLC to ensure no isomeric contamination, such as 3-Fluoro-6-nitrophenol, is present, which could alter reaction kinetics in nucleophilic substitution steps.
Benchmarking 98% Purity Grades and Impurity Profiles for 5-Fluoro-2-nitrophenol
Industrial purity grades often claim 98% assay, but the remaining 2% impurity profile dictates performance in sensitive coupling reactions. Trace impurities in nitrophenol derivatives can act as catalyst poisons or introduce color bodies that are difficult to remove in later purification stages. From a field engineering perspective, we have observed that trace metal ions or residual solvents from the manufacturing process can significantly affect the color stability of the final product during storage.
Specifically, 5-Fluoro-2-nitrophenol exhibits sensitivity to prolonged exposure to ambient light and oxygen. In practical handling scenarios, batches with inadequate stabilization may show a gradual shift from pale yellow to darker amber hues over time. This discoloration is not merely cosmetic; it often indicates oxidative degradation that can correlate with reduced yield in subsequent synthetic steps. Furthermore, during winter shipping conditions, we monitor for crystallization behavior. While the compound is a solid, improper temperature cycling can lead to caking or agglomeration, affecting dosing accuracy in automated dispensing systems. Our quality control protocols focus on minimizing these non-standard parameters to ensure consistent flowability and reactivity.
Essential COA Parameters for R&D Quality Control and Batch Release
For R&D managers, the COA is the contractual document defining quality. Beyond the basic assay, specific physical and chemical parameters must be reviewed to prevent batch rejection. When evaluating a new supplier, compare the provided data against your internal specifications for C6H4FNO3. Critical parameters include appearance, assay percentage, and melting point range. Since melting points can vary slightly based on calibration and sample preparation, always refer to the batch-specific COA for the exact numerical value rather than relying on general literature data.
The following table outlines the key technical parameters typically assessed during batch release for this intermediate:
| Parameter | Typical Specification | Test Method |
|---|---|---|
| Chemical Name | 5-Fluoro-2-nitrophenol | IUPAC |
| CAS Number | 446-36-6 | Registry |
| Molecular Formula | C6H4FNO3 | Calculated |
| Molecular Weight | 157.10 g/mol | Calculated |
| Assay (Purity) | ≥ 98.0% | HPLC/GC |
| Appearance | Light Yellow to Yellow Crystal | Visual |
| Moisture Content | ≤ 0.5% | Karl Fischer |
Ensuring moisture content is within limits is crucial, as excess water can interfere with anhydrous reaction conditions often required for fluorinated intermediates. Always request a retained sample for incoming quality control verification.
Bulk Packaging Options and Supply Chain Continuity for 5-Fluoro-2-nitrophenol
Supply chain continuity depends on robust physical packaging and reliable logistics. For bulk orders, we utilize standard industrial packaging suitable for hazardous chemicals, such as 25kg fiber drums or 210L steel drums, depending on the volume required. The choice of packaging material is critical to prevent moisture ingress and physical damage during transit. For international shipments, we adhere to strict physical packaging standards to ensure the integrity of the container remains intact upon arrival.
Factory direct sourcing allows for custom packaging configurations to suit specific laboratory or plant needs. Whether you require smaller quantities for pilot studies or bulk loads for full-scale manufacturing, the packaging is designed to maintain the stability of the 4-fluoro-2-hydroxy-1-nitrobenzene structure. We focus on the physical security of the goods, ensuring that labels are clear and handling instructions are visible to logistics personnel. This approach minimizes the risk of delays at customs due to packaging non-compliance, focusing strictly on the physical transport requirements rather than regulatory environmental guarantees.
Specification Mapping for Sigma Aldrich and Thermo Fisher 5-Fluoro-2-nitrophenol Alternatives
Many research teams seek a 5-Fluoro-2-Nitrophenol Sigma Aldrich Alternative to reduce costs or secure larger volumes not available through standard catalog channels. The goal of specification mapping is to ensure that the alternative source matches the technical performance of the previously used material. By aligning our manufacturing process with the high purity standards expected in pharmaceutical intermediates, we facilitate a seamless transition.
Our production capabilities support scale-up production without compromising the impurity profile. You can review our detailed product specifications and request samples for validation at 5-Fluoro-2-nitrophenol high purity organic synthesis intermediate. This allows your technical team to run side-by-side comparisons in your specific synthesis route. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing data-driven support to confirm that our material meets your process requirements.
Frequently Asked Questions
What is the standard purity level for industrial grades?
Industrial grades typically start at 98% purity, but specific application requirements may necessitate higher assays. Please refer to the batch-specific COA for exact numbers.
Can you provide custom packaging for laboratory use?
Yes, we offer custom packaging options including smaller drums or lined containers to suit laboratory and pilot plant needs.
How do you ensure identity validation for CAS 446-36-6?
We utilize HPLC and NMR spectroscopy to confirm the chemical identity matches the C6H4FNO3 formula before batch release.
What is the lead time for bulk orders?
Lead times vary based on inventory and production schedules. Contact our procurement team for current availability and shipping estimates.
Sourcing and Technical Support
Securing a reliable supply of critical intermediates requires a partner with transparent technical data and robust manufacturing capabilities. We prioritize engineering excellence and supply chain stability to support your R&D and production goals. Partner with a verified manufacturer. Connect with our procurement specialists to lock in your supply agreements.