Intermediates

5-Fluoro-2-nitrophenol

  • CAS No.446-36-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 5-Fluoro-2-nitrophenol (CAS 446-36-6) designed for advanced organic synthesis applications with ≥99.0% assay guarantee.

Request Bulk Pricing

Product Technical Details

Product Overview

5-Fluoro-2-nitrophenol is a specialized fluorinated aromatic compound extensively utilized in the pharmaceutical and agrochemical industries as a critical building block. This nitrophenol derivative features a unique substitution pattern that enhances its reactivity in nucleophilic aromatic substitution reactions. Our manufacturing process ensures consistent quality and high purity levels, making it an ideal choice for complex organic synthesis pathways where precision and reliability are paramount.

As a key intermediate, this compound facilitates the introduction of fluorine atoms into molecular structures, significantly improving the metabolic stability and bioavailability of final active pharmaceutical ingredients. The presence of both nitro and hydroxyl groups provides versatile sites for further chemical modification, allowing chemists to develop a wide range of downstream derivatives efficiently.

Key Specifications

PropertySpecification
CAS Number446-36-6
Molecular FormulaC6H4FNO3
Molecular Weight157.099 g/mol
AppearanceLight yellow liquid
Assay≥99.0%
Moisture Content≤0.2%
Melting Point34-37 °C
Boiling Point228.5±20.0 °C at 760 mmHg
Density1.5±0.1 g/cm3
Flash Point91.7±0.0 °C

Industrial Applications

This fluorinated intermediate is primarily employed in the synthesis of high-value pharmaceuticals, including kinase inhibitors and anti-inflammatory agents. The electron-withdrawing nature of the nitro group combined with the fluorine substituent activates the aromatic ring for specific coupling reactions. It is also valuable in the production of advanced agrochemicals where fluorine incorporation enhances pesticide efficacy and environmental stability.

Researchers utilize this material for developing novel heterocyclic compounds and liquid crystal materials. Its stability under standard storage conditions allows for flexible logistics and inventory management for large-scale production facilities. The compound serves as a reliable precursor for creating diverse chemical libraries used in drug discovery programs.

Quality Assurance and Logistics

We adhere to strict quality control protocols throughout the manufacturing process. Every batch undergoes rigorous testing using high-performance liquid chromatography and gas chromatography to verify purity and identity. A comprehensive Certificate of Analysis is provided with each shipment to ensure compliance with international standards.

  • Global shipping capabilities with secure packaging
  • Custom packaging options available upon request
  • Technical support for synthesis route optimization
  • Competitive bulk pricing for long-term partnerships

Storage recommendations include keeping the container tightly closed in a cool, ventilated area away from incompatible substances. Proper handling procedures should be followed to maintain product integrity and ensure workplace safety. Contact our sales team for detailed safety data sheets and current availability.