2-Fluoro-5-Formylbenzonitrile Bulk Price 2026 Global Manufacturer
- Market Stability: Forecasted bulk price trends indicate stable costs for fluorinated intermediates through 2026 due to optimized manufacturing processes.
- Quality Standards: Industrial purity levels exceed 98.5% with comprehensive COA documentation for regulatory compliance.
- Supply Chain: Global manufacturer capabilities ensure consistent stock levels for large-scale pharmaceutical production.
In the rapidly evolving landscape of medicinal chemistry, securing a reliable supply chain for key intermediates is paramount. 2-Fluoro-5-formylbenzonitrile (CAS: 218301-22-5) serves as a critical building block, particularly in the synthesis of PARP inhibitors such as Olaparib. As demand scales, procurement managers must evaluate not only the bulk price but also the technical consistency and logistical reliability of their supply partners. NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier global manufacturer dedicated to providing high-quality chemical intermediates with transparent pricing structures and robust quality assurance protocols.
Understanding the technical specifications is the first step in vendor qualification. This compound, also known synonymously as 3-Cyano-4-fluorobenzaldehyde, requires precise handling due to its reactivity and specific physical properties. The following table outlines the essential chemical data required for safety data sheets and process engineering.
| Property | Specification |
|---|---|
| CAS Number | 218301-22-5 |
| Molecular Formula | C8H4FNO |
| Molecular Weight | 149.13 g/mol |
| Melting Point | 80-84°C |
| MDL Number | MFCD01863558 |
| Hazard Class | Irritant (H317, H319) |
| Storage Conditions | Under Argon/Nitrogen |
Comparative Analysis of Online vs Bulk Wholesale Pricing
Procurement strategies for fine chemicals often bifurcate between small-scale online purchasing and direct bulk wholesale contracts. While online catalog prices offer immediate availability for gram-scale research, they rarely reflect the true cost efficiency required for commercial production. The bulk price for 2-Fluoro-5-formylbenzonitrile is significantly influenced by the synthesis route employed by the manufacturer. Efficient fluorination and formylation processes reduce waste and energy consumption, passing savings to the buyer.
Buyers must scrutinize the quoted price against the stated industrial purity. Lower-cost options found on generic marketplaces often lack rigorous purification steps, resulting in impurities that can catalyze side reactions during downstream synthesis. A reputable supplier will provide detailed impurity profiles alongside the standard Certificate of Analysis. When evaluating suppliers for 2-Fluoro-5-formylbenzonitrile, buyers should prioritize vendors who demonstrate control over the entire manufacturing process rather than mere distributors. This ensures traceability and consistent batch-to-batch reproducibility, which is critical for regulatory filings in the pharmaceutical sector.
Volume Discount Structures for Pharmaceutical Intermediates
Volume-based pricing models are standard in the B2B chemical industry, but the tiers vary significantly based on production capacity. For a nitrile derivative of this complexity, manufacturers typically offer distinct pricing tiers for kilogram, multi-kilogram, and metric ton quantities. NINGBO INNO PHARMCHEM CO.,LTD. structures its discounts to reward long-term partnerships and large-volume commitments, ensuring that scale-up from clinical trials to commercial manufacturing remains cost-effective.
It is essential to note that volume discounts should not come at the expense of quality assurance. High-volume orders must still undergo full analytical validation. The COA provided with bulk shipments should match the specifications of the initial qualification batch. Deviations in melting point (outside the 80-84°C range) or purity can indicate issues in the crystallization process. Furthermore, custom synthesis options are often available for clients requiring specific particle sizes or packaging configurations, which can be negotiated within the volume contract framework.
Logistics and Cold-Chain Transportation Cost Factors
The logistical framework for shipping fluorinated intermediates involves strict adherence to safety regulations and stability requirements. As indicated in the hazard information, this compound may cause an allergic skin reaction (H317) and serious eye irritation (H319). Consequently, packaging must be robust, often utilizing double-lined drums or specialized containers that prevent moisture ingress. The requirement to store contents under argon or nitrogen implies that bulk packaging must maintain an inert atmosphere during transit to prevent oxidation of the aldehyde group.
Transportation costs are a significant component of the landed cost, especially for international shipments. A capable global manufacturer will have established relationships with freight forwarders specializing in hazardous materials. Cold-chain transportation is not always mandatory but is recommended for long-duration shipments to maintain industrial purity. Buyers should request a breakdown of logistics costs separately from the product price to accurately compare offers. Additionally, ensuring the supplier can provide Certificates of Origin (COO) is vital for customs clearance and duty optimization in various jurisdictions.
In summary, securing a stable supply of 2-Fluoro-5-formylbenzonitrile requires a partner who understands both the chemical nuances and the commercial realities of the pharmaceutical supply chain. By focusing on verified synthesis routes, transparent bulk price structures, and compliant logistics, manufacturers can mitigate risk and ensure production continuity. NINGBO INNO PHARMCHEM CO.,LTD. remains committed to delivering these standards, supporting clients from early-stage organic synthesis through to full-scale commercial production.