2-Fluoro-5-formylbenzonitrile
- CAS No.218301-22-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity pharmaceutical intermediate used in the synthesis of Olaparib and other kinase inhibitors. Available in bulk quantities with full documentation.
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Product Overview
2-Fluoro-5-formylbenzonitrile is a specialized fluorinated organic compound serving as a critical building block in modern medicinal chemistry. Characterized by its unique substitution pattern featuring both a nitrile group and an aldehyde moiety on a fluorobenzene ring, this chemical enables precise structural modifications during complex synthesis routes. Our facility produces this intermediate under strict quality control standards to ensure consistency for downstream pharmaceutical manufacturing.
The introduction of fluorine atoms into organic molecules is a strategic approach in drug design to enhance metabolic stability and bioavailability. This specific compound acts as a versatile precursor for constructing heterocyclic systems found in various therapeutic agents. We specialize in supplying high-purity grades suitable for large-scale production environments.
Technical Specifications
We maintain rigorous testing protocols for every batch to guarantee compliance with international pharmaceutical standards. The following table outlines the key physical and chemical parameters verified by our quality assurance team.
| Parameter | Specification |
|---|---|
| Chemical Name | 2-Fluoro-5-formylbenzonitrile |
| CAS Number | 218301-22-5 |
| Molecular Formula | C8H4FNO |
| Molecular Weight | 149.12 g/mol |
| Appearance | Off-white to pale yellow powder |
| Purity (HPLC) | ≥98.0% |
| Melting Point | 80-84°C |
| Boiling Point | 211.9°C |
| Density | 1.265 g/cm3 |
Industrial Applications
This compound is primarily utilized as a key intermediate in the synthesis of poly ADP-ribose polymerase (PARP) inhibitors. Notably, it serves as a crucial starting material in the manufacturing process of Olaparib, a prominent oncology therapeutic. Beyond this specific application, the reactivity of the formyl and nitrile groups allows chemists to develop diverse libraries of compounds for drug discovery programs.
- Synthesis of targeted cancer therapeutics and kinase inhibitors.
- Construction of complex heterocyclic scaffolds in medicinal chemistry.
- Development of novel fluorinated organic materials for research.
- Custom synthesis projects requiring high-purity fluorinated building blocks.
Quality Assurance and Logistics
Our commitment to quality extends beyond the final product. We implement comprehensive analytical methods including HPLC, NMR, and Mass Spectrometry to validate identity and purity. Each shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. We understand the importance of supply chain reliability for our manufacturing partners.
Products are packaged in secure 25 kg drums or according to specific customer requirements to prevent moisture absorption and contamination. Storage recommendations include keeping the material in a cool, ventilated area away from direct sunlight and oxidizing agents. We offer global shipping capabilities with full documentation support to ensure smooth customs clearance for legitimate pharmaceutical research and production facilities.
