10,11-Dihydro-11-Oxodibenzo[B,F][1,4]Thiazepine Bulk Price 2026
- Market Pricing: Laboratory-scale prices vary significantly, but industrial bulk procurement offers substantial cost reductions for CAS 3159-07-7.
- Technical Specs: Critical purity standards (HPLC ≥98%) and physical properties must be verified via COA before scaling synthesis.
- Supply Chain: Partnering with a dedicated global manufacturer ensures consistent quality for pharmaceutical intermediate production.
The pharmaceutical landscape for antipsychotic medications continues to drive demand for key intermediates, specifically 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine (CAS: 3159-07-7). As we approach 2026, procurement managers and process chemists must navigate a complex market where laboratory reagent pricing often obscures the true cost of industrial-scale production. This compound, frequently identified in technical literature as Dibenzo[b,f][1,4]thiazepin-11(10H)-one, serves as a critical building block in the synthesis of Quetiapine. Understanding the divergence between small-batch reagent costs and true manufacturing volumes is essential for maintaining margin integrity in generic pharmaceutical production.
Global Bulk Pricing Trends for CAS 3159-07-7 in 2026
Market analysis indicates a wide disparity in pricing structures depending on the quantity and purity grade required. Data aggregated from various chemical suppliers suggests that small-scale packaging (5g to 25g) often commands a premium price per gram, ranging significantly due to branding and packaging overheads. For instance, entry-level reagent grades may appear affordable at small quantities, but the cost per kilogram escalates rapidly without negotiated bulk contracts. Conversely, industrial procurement focuses on the bulk price per metric ton or large drum quantities, where economies of scale drastically reduce the unit cost.
For process development moving into commercialization, relying on catalog pricing is inefficient. The market shows that while 100g packages might cost between $130 and $380 depending on the vendor, bulk industrial orders should be negotiated directly with production facilities. The following table outlines estimated pricing tiers based on current market intelligence, anonymized to reflect general industry standards rather than specific vendor lists.
| Quantity Tier | Estimated Price Range (USD) | Typical Purity Grade | Procurement Channel |
|---|---|---|---|
| Laboratory Scale (5g - 25g) | $50 - $200 | 95% - 98% | Reagent Catalogs |
| Pilot Scale (100g - 1kg) | $150 - $500 | ≥98% (HPLC) | Specialized Distributors |
| Industrial Bulk (5kg - 25kg+) | Request Quote | Industrial Purity / Custom | Direct Manufacturer |
Factors Influencing Industrial-Scale Procurement Costs
Several technical variables dictate the final cost of goods for this thiazepine derivative. The primary factor is the synthesis route employed by the manufacturer. Efficient cyclization methods that maximize yield while minimizing hazardous waste disposal costs will naturally offer more competitive pricing. Furthermore, the removal of impurities such as residual solvents or unreacted starting materials requires rigorous purification steps, which impacts the final industrial purity profile.
Buyers must also consider the physical properties during storage and transport. The compound typically presents as a white to off-white solid with a melting point around 265 °C. It requires storage in a dark place, sealed in dry conditions at 2-8°C to maintain stability. Degradation during transit due to improper temperature control can lead to significant financial loss, emphasizing the need for a supply chain with robust quality assurance protocols. When evaluating vendors, requesting a comprehensive COA (Certificate of Analysis) is non-negotiable to verify parameters like density (approx. 1.292 g/cm³) and boiling point predictions.
Technical Specifications and Quality Standards
To ensure compatibility with downstream pharmaceutical processes, the intermediate must meet strict physicochemical criteria. The molecular formula C13H9NOS and molecular weight of 227.28 g/mol are standard, but the structural integrity is paramount. High-performance liquid chromatography (HPLC) is the standard method for verifying assay purity, with most commercial applications requiring ≥98% purity to prevent contamination of the final active pharmaceutical ingredient (API).
For organizations seeking to secure a reliable supply chain for 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine, technical due diligence is required. The material should be soluble in DMSO (slightly, heated) for analytical testing, and safety data sheets must reflect GHS Warning symbols regarding handling. A reputable global manufacturer will provide full traceability from raw material sourcing to the final packaged product, ensuring compliance with international regulatory standards.
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 3159-07-7 | Verified |
| Appearance | White to Off-White Solid | Visual |
| Melting Point | 265 °C | Capillary / DSC |
| Purity (HPLC) | ≥ 98.0% | Area Normalization |
| Storage Conditions | 2-8°C, Dark, Dry | Stability Study |
How to Source High-Purity Dibenzo[b,f][1,4]thiazepin-11(10H)-one at Competitive Rates
Securing a stable supply for 2026 and beyond requires moving beyond transactional purchasing relationships. Pharmaceutical manufacturers should prioritize partnerships with entities that control the manufacturing process rather than mere distributors. This ensures that any custom synthesis requirements or scale-up adjustments can be managed efficiently without disrupting the production timeline.
NINGBO INNO PHARMCHEM CO.,LTD. stands out as a premier partner in this sector, offering direct manufacturing capabilities that bypass intermediary markups. By engaging directly with a top-tier manufacturer, procurement teams can negotiate volume-based pricing that reflects true production costs rather than inflated catalog rates. Additionally, direct manufacturers are better equipped to handle custom packaging requirements and provide consistent batch-to-batch reproducibility, which is critical for regulatory filings.
In conclusion, while market data shows a wide range of pricing for CAS 3159-07-7, the most cost-effective strategy for 2026 involves direct engagement with established chemical producers. Focusing on technical specifications, verifying purity through rigorous COA review, and establishing a direct line to a capable manufacturing partner will ensure both economic efficiency and supply chain security for your pharmaceutical intermediates.