Methyl 2-Cyanopyridine-4-Carboxylate Bulk Price Global Manufacturer 2026
- Volume-Based Pricing: Tiered discount structures available for metric ton-scale procurement.
- Technical Specifications: Guaranteed industrial purity exceeding 98.5% via HPLC analysis.
- 2026 Availability: Stable supply chain commitments with lead times under 4 weeks for bulk orders.
In the evolving landscape of pharmaceutical intermediates, securing a stable supply of high-quality heterocyclic building blocks is critical for process development and commercial manufacturing. NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier global manufacturer dedicated to delivering consistent quality and competitive commercial terms for essential chemical entities. As we approach 2026, understanding the market dynamics, synthesis capabilities, and procurement strategies for Methyl 2-cyanopyridine-4-carboxylate (CAS: 94413-64-6) is vital for supply chain managers and procurement officers.
This compound, also known systematically as 2-Cyano-4-pyridine carboxylic acid methyl ester, serves as a pivotal organic building block in the synthesis of complex drug molecules. Its unique electronic properties make it indispensable for constructing antibacterial and cardiovascular therapeutic agents. This article provides a technical and commercial overview designed for B2B buyers seeking reliable bulk supply partners.
Technical Specifications and Synthesis Route Optimization
The commercial viability of any intermediate relies heavily on the robustness of its production method. Our manufacturing process utilizes an optimized synthesis route that prioritizes yield maximization and impurity control. The production typically begins with a substituted pyridine derivative, undergoing nucleophilic substitution to introduce the cyano group followed by esterification.
Critical process parameters include strict temperature control during the cyanation step to prevent side reactions such as hydrolysis of the nitrile group. Subsequent esterification with methanol is catalyzed under acidic conditions to ensure complete conversion. The final product is purified through vacuum distillation or recrystallization to achieve industrial purity standards suitable for GMP environments.
When sourcing high-purity Methyl 2-cyanoisonicotinate, buyers should verify the certificate of analysis for specific impurity profiles, particularly related to unreacted starting materials or isomeric byproducts. Our facility employs rigorous QC protocols, including GC-MS and HPLC, to ensure each batch meets the stringent requirements of pharmaceutical grade applications.
Physical and Chemical Properties
Understanding the physicochemical profile is essential for handling and processing. The compound typically presents as a colorless to light yellow liquid or crystalline solid depending on the specific batch crystallization. It exhibits high solubility in common organic solvents such as dichloromethane, ethanol, and ether, while maintaining limited solubility in water. This profile facilitates efficient extraction and purification workflows during downstream synthesis.
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 94413-64-6 | - |
| Purity (HPLC) | > 98.5% | Area Normalization |
| Appearance | Colorless to Light Yellow Liquid/Crystal | Visual |
| Moisture Content | < 0.5% | Karl Fischer |
| Storage Stability | 24 Months (Cool, Dry) | Accelerated Aging |
Volume-Based Pricing Tiers for Bulk Orders
The bulk price of Methyl 2-cyanopyridine-4-carboxylate is influenced by raw material costs, energy consumption during synthesis, and order volume. As a global manufacturer, we offer transparent pricing structures that reward long-term partnerships and large-scale commitments. Pricing is dynamic and subject to market fluctuations in pyridine derivatives and cyanide reagents, but volume tiers provide stability for budget forecasting.
Procurement officers should note that prices for kilogram-scale laboratory requests differ significantly from metric ton contracts. Large-scale production runs allow for optimized reactor utilization and reduced per-unit logistics costs, resulting in more favorable commercial terms.
| Order Volume | Price Tier | Lead Time | Payment Terms |
|---|---|---|---|
| 1 kg - 25 kg | Standard Laboratory Rate | 3-5 Days | 100% Prepayment |
| 25 kg - 100 kg | Pilot Scale Discount | 7-10 Days | 50% Deposit |
| 100 kg - 1 Ton | Commercial Bulk Rate | 2-3 Weeks | LC or OA (Approved) |
| > 1 Ton | Contract Manufacturing Price | 4 Weeks | Negotiated |
Global Supply Chain and Logistics Compliance
Reliable delivery is as crucial as product quality. Our logistics network ensures compliant shipping across international borders, adhering to all relevant safety regulations for chemical transport. Proper documentation, including Safety Data Sheets (SDS) and non-hazardous transport certifications where applicable, is provided with every shipment.
Storage conditions play a vital role in maintaining product integrity during transit and warehousing. The compound must be stored in a cool, dry place, sealed in airtight containers to prevent moisture ingress which could lead to hydrolysis of the ester or nitrile groups. Containers should be kept away from fire and heat sources to mitigate any flammability risks associated with organic solvents used in processing.
2026 Market Availability and Lead Times
Looking toward 2026, market availability for this heterocyclic intermediate remains stable due to diversified raw material sourcing. However, demand from the fine chemical and pharmaceutical sectors is projected to increase. Early reservation of production capacity is recommended for buyers requiring consistent supply throughout the year.
Lead times are generally maintained within 4 weeks for standard bulk orders. Custom synthesis requests or specific packaging requirements may extend this timeline slightly. Our production planning team works closely with clients to align manufacturing schedules with their downstream process needs, minimizing inventory holding costs.
Quality Assurance and Documentation
Transparency in quality assurance is a cornerstone of our service. Every batch is accompanied by a comprehensive COA (Certificate of Analysis). If a specific batch COA is not immediately available on the digital portal, clients can request it directly through our customer support channels by providing the product name and batch number.
Our quality assurance team ensures that all technical data is accurate and verifiable. Follow-up on documentation requests is standard procedure to ensure no delays in your inbound quality control processes. This commitment to documentation supports regulatory filings and audit readiness for our partners.
Conclusion
Securing a reliable source for Methyl 2-cyanopyridine-4-carboxylate requires a partner with technical expertise and commercial flexibility. NINGBO INNO PHARMCHEM CO.,LTD. combines advanced manufacturing capabilities with a customer-centric approach to meet the demands of the 2026 market. By focusing on industrial purity, optimized synthesis routes, and transparent pricing, we empower our clients to innovate without supply chain constraints.
For detailed quotations or technical inquiries regarding custom synthesis options, please contact our sales team. We are committed to providing safe, efficient, and compliant chemical solutions that drive your success.