Bulk Price Dimethyl (3-Oxo-1,3-Dihydroisobenzofuran-1-Yl)Phosphonate 2026
- 2026 Market Outlook: Stabilizing raw material costs are expected to optimize bulk price structures for CAS 61260-15-9.
- Technical Specifications: Industrial purity standards typically exceed 95%, verified by HPLC and NMR analysis.
- Procurement Strategy: Partnering with a global manufacturer ensures consistent supply chains and comprehensive COA documentation.
The pharmaceutical intermediate market is undergoing significant shifts as we approach 2026, particularly for key building blocks used in oncology drug synthesis. Among these, CAS 61260-15-9 represents a critical component in the production of PARP inhibitors. Procurement managers and process chemists must understand the technical and commercial factors driving the bulk price of this specialized phosphonate. This analysis provides a detailed overview of cost drivers, quality parameters, and supply chain considerations for large-scale acquisition.
Current Bulk Pricing Trends for CAS 61260-15-9 in 2026
The pricing landscape for complex heterocyclic phosphonates is influenced by the availability of precursor chemicals and energy costs associated with multi-step synthesis. In 2026, market data suggests a stabilization in costs due to improved manufacturing efficiencies in East Asian production hubs. However, fluctuations in the price of dimethyl phosphite and phthalide derivatives can impact the final bulk price. Buyers securing long-term contracts often mitigate these risks, locking in favorable rates compared to spot market purchases.
Demand is primarily driven by the continued production of generic oncology therapies. As patents expire for major blockbuster drugs utilizing this intermediate, volume requirements increase. Consequently, suppliers are scaling up reactor capacities to meet kilogram and ton-level demands. This economies-of-scale effect is crucial for maintaining competitive pricing without compromising on the industrial purity required for GMP manufacturing environments.
Technical Specifications and Manufacturing Process
From a synthetic chemistry perspective, the quality of Dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate is defined by its isomeric purity and residual solvent content. The compound, also known technically as 3-dimethoxyphosphoryl-3H-2-benzofuran-1-one, requires precise control during the phosphorylation step to prevent the formation of side products. A robust synthesis route typically involves the reaction of 3-hydroxyphthalide with dimethyl phosphite under catalytic conditions, followed by rigorous purification.
When sourcing high-purity Dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate, buyers should verify that the manufacturer employs advanced chromatographic techniques for final isolation. Standard specifications usually dictate a purity profile of 95% or higher, with strict limits on heavy metals and organic volatile impurities. The molecular formula C10H11O5P and molecular weight of 242.17 g/mol must align with mass spectrometry data provided in the technical dossier.
Quality assurance is non-negotiable in pharmaceutical supply chains. A comprehensive COA (Certificate of Analysis) should include data from proton NMR, carbon NMR, and high-performance liquid chromatography. These documents confirm the structural integrity of the phosphonate group and the lactone ring, ensuring the intermediate will perform predictably in downstream coupling reactions.
Standard Technical Parameters
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 61260-15-9 | N/A |
| Chemical Name | Dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate | IUPAC |
| Molecular Formula | C10H11O5P | Elemental Analysis |
| Molecular Weight | 242.17 g/mol | Mass Spectrometry |
| Purity | > 95.0% | HPLC |
| Appearance | White to Off-White Solid | Visual |
Factors Influencing Industrial-Scale Procurement Costs
Several variables dictate the final landed cost for industrial buyers. First, the packaging configuration plays a role; bulk drums (25kg) are more cost-effective per kilogram than smaller laboratory bottles. Second, logistics and hazardous material handling fees can vary based on the classification of the phosphonate during transport. While generally stable, proper documentation is required for international shipping.
Furthermore, the level of custom synthesis support required can affect pricing. Some projects require specific particle size distribution or custom drying protocols to meet downstream processing needs. A global manufacturer with flexible R&D capabilities can accommodate these requests, though they may incur additional technical service charges. It is essential to clarify these requirements during the request for quotation (RFQ) phase to avoid unexpected costs later in the procurement cycle.
How to Request Custom Quotations from Global Manufacturers
To secure the best value for CAS 61260-15-9, procurement teams should engage directly with established chemical producers rather than general trading companies. Direct engagement ensures transparency regarding the manufacturing process and source of raw materials. When initiating contact, provide detailed information regarding your annual volume requirements, desired purity thresholds, and target delivery timelines.
NINGBO INNO PHARMCHEM CO.,LTD. stands out as a premier partner for such specialized intermediates, offering robust supply chain solutions and technical expertise. By collaborating with a dedicated entity like NINGBO INNO PHARMCHEM CO.,LTD., clients gain access to consistent batch-to-b quality and reliable lead times. This reliability is critical for maintaining continuous production lines in the competitive pharmaceutical sector.
In conclusion, the 2026 outlook for this phosphonate intermediate remains positive, with supply chains maturing to meet oncology drug demand. By focusing on technical verification, understanding cost drivers, and selecting the right manufacturing partner, organizations can optimize their procurement strategies for long-term success.