2-Chloro-5-Fluoro-4-Iodopyridine Bulk Price Global Manufacturer 2026
- Industrial Purity: Guaranteed ≥95% purity with comprehensive COA documentation for every batch.
- Volume Pricing: Tiered discount structures available for multi-kilogram and metric ton orders.
- Global Supply: Reliable logistics network ensuring timely delivery of critical pharmaceutical intermediates worldwide.
In the rapidly evolving landscape of organic synthesis, the demand for specialized heterocyclic building blocks continues to surge. Among these, 2-Chloro-5-fluoro-4-iodopyridine (CAS: 884494-49-9) stands out as a critical pharmaceutical intermediate used in the development of kinase inhibitors and agrochemical agents. As we approach 2026, procurement strategies must focus not only on cost but on supply chain reliability and technical specifications. NINGBO INNO PHARMCHEM CO.,LTD. establishes itself as a premier global manufacturer capable of meeting these rigorous standards through advanced manufacturing process controls and scalable production capabilities.
This halogenated heterocycle offers unique reactivity profiles due to the differential leaving group abilities of the chlorine, fluorine, and iodine substituents. This allows chemists to perform selective cross-coupling reactions, such as Suzuki-Miyaura or Sonogashira couplings, at specific positions on the pyridine ring. For process chemists scaling up reactions, maintaining industrial purity is paramount to ensuring consistent reaction yields and minimizing downstream purification costs.
Technical Specifications and Quality Standards
Understanding the physicochemical properties of this Pyridine derivative is essential for safe handling and effective integration into synthesis workflows. The following table outlines the key specifications required for quality assurance during bulk procurement.
| Parameter | Specification |
|---|---|
| Product Name | 2-Chloro-5-fluoro-4-iodopyridine |
| CAS Number | 884494-49-9 |
| Molecular Formula | C5 H2 Cl F I N |
| Molecular Weight | 257.432 g/mol |
| MDL Number | MFCD03095306 |
| Purity | ≥ 95% (GC/HPLC) |
| Appearance | Off-white to Light Yellow Solid |
When sourcing high-purity 2-Chloro-5-fluoro-4-iodopyridine, buyers should verify that the supplier provides detailed impurity profiles. Trace metals or isomeric impurities can significantly impact catalytic cycles in later synthesis stages. Our facility utilizes rigorous chromatographic analysis to ensure that each batch meets the specified purity thresholds before shipment.
Volume Discount Structures for Large Orders
Procurement costs for specialized Halogenated pyridine compounds vary significantly based on order volume. Spot pricing for gram-scale quantities is inherently higher due to packaging and handling overheads. However, commercial-scale projects require kilogram to metric ton quantities, where economies of scale apply.
At NINGBO INNO PHARMCHEM CO.,LTD., we offer structured pricing tiers designed to support R&D through to commercial production. Discounts are typically applied when orders exceed five times the largest standard pack size. For instance, transitioning from 100g bottles to 25kg drums can reduce the unit cost substantially. Clients are encouraged to request a formal quotation specifying their annual consumption forecasts to lock in favorable bulk price rates for the 2026 fiscal year.
Key Factors Influencing Pricing
- Raw Material Availability: Fluctuations in iodine and fluorine source costs can impact final pricing.
- Synthesis Route: Optimized synthesis route efficiency lowers production costs, savings which are passed to the client.
- Packaging Requirements: Custom packaging for hazardous materials may incur additional fees compared to standard drums.
Global Logistics and Shipping Options
Reliable delivery is as critical as chemical quality. As a global manufacturer, we manage complex logistics to ensure hazardous chemicals reach international destinations compliant with IATA and IMDG regulations. 2-Chloro-5-fluoro-4-iodopyridine is classified under specific hazardous material codes due to its iodine content and potential reactivity.
Shipping options include air freight for urgent R&D needs and sea freight for cost-effective bulk transfers. All shipments are accompanied by necessary documentation, including Safety Data Sheets (SDS) and Certificates of Analysis (COA). Proper packaging ensures stability during transit, preventing degradation from moisture or light exposure.
Quality Assurance and COA Retrieval
Documentation is the backbone of pharmaceutical supply chains. In cases where a Certificate of Analysis (COA) is not immediately visible on a digital platform, a structured protocol ensures quick retrieval. Buyers should first check the website sitemap to ensure all available technical documents have been searched. If the document remains unavailable, direct contact with customer support via email or phone is the next step.
When submitting a request, provide the product name, specific batch number, and contact information explicitly stating the need for the COA. Follow-up communications should be recorded to ensure timely resolution. This transparency guarantees that the organic building block received matches the technical requirements of your process development team.
2026 Market Price Forecast and Trends
Looking toward 2026, the market for fluorinated and iodinated pyridines is expected to remain robust. Demand is driven by the pipeline of novel oncology drugs and crop protection agents requiring precise halogenation patterns. While raw material costs may fluctuate, advancements in continuous flow chemistry are expected to stabilize production costs for key intermediates.
Strategic partnerships with manufacturers who invest in process optimization will mitigate supply risks. Companies securing long-term contracts now may avoid potential price spikes associated with global supply chain disruptions. By prioritizing suppliers with proven industrial purity standards and scalable capacity, procurement managers can ensure uninterrupted production schedules.
In conclusion, securing a reliable supply of 2-Chloro-5-fluoro-4-iodopyridine requires a partner who understands both the chemistry and the commercial landscape. With a focus on technical excellence and customer support, we remain committed to powering your synthesis goals through 2026 and beyond.