Ethylene Glycol-bis(Succinic Acid N-Hydroxysuccinimide Ester): A Powerful Tool for Bioconjugation
Discover the versatile applications of this homobifunctional, cleavable crosslinker, ideal for precise biomolecule modification and analysis in life science research.
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Ethylene Glycol-bis(Succinic Acid N-Hydroxysuccinimide Ester)
As a leading supplier in China, we provide Ethylene Glycol-bis(Succinic Acid N-Hydroxysuccinimide Ester), a critical reagent for various biological applications. This homobifunctional, cleavable crosslinker is designed to link molecules containing primary amines via amide bonds, offering a stable yet cleavable 12-atom spacer arm. Its high purity and reliable performance make it an essential component for researchers advancing fields such as ChIP assays and protein labeling.
- Explore precise molecular interactions using this homobifunctional crosslinker for ChIP assays, ensuring accurate DNA-protein binding studies.
- Leverage the amine-reactive NHS esters to achieve efficient bioconjugation, a key process in developing diagnostic tools and therapeutics.
- Benefit from a versatile chemical linker with a cleavable spacer arm, allowing for controlled release or modification in complex biological systems.
- Understand the significance of cleavable crosslinking reagents in biomolecule modification for advanced research applications.
Key Advantages Offered
High Reactivity and Specificity
The amine-reactive NHS esters ensure efficient coupling to primary amines under mild conditions, making it a preferred choice for sensitive biomolecules and understanding DNA-protein binding interactions.
Cleavable Linker Technology
The ethylene glycol spacer arm is cleavable by hydroxylamine, providing flexibility in experimental design and enabling controlled release or modification, which is crucial for certain bioconjugation strategies.
Versatile Applications in Research
This reagent is widely adopted in molecular biology for protein crosslinking, antibody-drug conjugate synthesis, and particularly in ChIP assays, demonstrating its broad utility in scientific discovery.
Key Applications
Bioconjugation
Utilize this homobifunctional crosslinker to create stable conjugates between proteins, antibodies, or other biomolecules, facilitating the development of new diagnostic and therapeutic agents.
ChIP Assays
Enhance the accuracy of Chromatin Immunoprecipitation (ChIP) assays by effectively crosslinking DNA-bound proteins, which is critical for studying gene regulation and protein-DNA interactions.
Protein Stabilization
Employ EGS to stabilize protein structures or create specific crosslinks within proteins, which can be beneficial for structural biology studies and enzyme engineering.
Drug Delivery Systems
Explore its potential in developing advanced drug delivery systems by conjugating therapeutic agents to targeting molecules or carriers, optimizing treatment efficacy.