Biotin-PEG(3)-SH: Advanced Linker for Bioconjugation and PROTAC Synthesis
Unlock advanced molecular strategies with Biotin-PEG(3)-SH, a high-purity PEG linker essential for sophisticated bioconjugation and PROTAC development. Discover its unique functionalities for your research.
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Biotin-PEG(3)-SH
As a leading supplier in China, we offer Biotin-PEG(3)-SH, a critical component for researchers in drug discovery and biotechnology. Its carefully designed structure combines a biotin moiety for robust interaction with avidin and streptavidin with a terminal thiol group, enabling versatile conjugation via thiol-reactive chemistry. This heterobifunctional PEG linker is instrumental in developing PROTACs and other targeted therapeutic agents, offering enhanced solubility and stability to the conjugated molecules. Our commitment as a manufacturer in China ensures high purity and reliable performance for your demanding research needs.
- Leverage Biotin-PEG(3)-SH for efficient PROTAC synthesis, ensuring precise molecular targeting.
- Utilize its thiol-reactive chemistry for seamless bioconjugation, creating complex biomolecular assemblies.
- Enhance your drug delivery systems with PEGylation strategies, improving pharmacokinetics and biodistribution.
- Explore cutting-edge applications in diagnostics and biomaterial functionalization using biotinylation chemistry in drug discovery.
Key Advantages Offered
Versatile Conjugation Capabilities
The terminal thiol group of Biotin-PEG(3)-SH allows for straightforward conjugation with various molecules, including maleimides and haloacetyl derivatives, making it a flexible tool for diverse bioconjugation applications.
Enhanced Biocompatibility
The polyethylene glycol (PEG) spacer in Biotin-PEG(3)-SH improves the solubility and biocompatibility of the final conjugate, reducing immunogenicity and prolonging circulation half-life, which is crucial for drug delivery.
High Affinity Binding
The integrated biotin moiety provides exceptional affinity for avidin and streptavidin, enabling sensitive detection and specific targeting in various assay formats and diagnostic tools.
Key Applications
PROTAC Development
Biotin-PEG(3)-SH serves as a critical linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating the degradation of target proteins.
Bioconjugation Assays
Its dual functionality makes it ideal for labeling proteins, antibodies, and nucleic acids for various biochemical assays and diagnostic platforms.
Drug Delivery Systems
PEGylation with Biotin-PEG(3)-SH can improve the pharmacokinetic properties and targeting capabilities of therapeutic payloads.
Biomaterial Functionalization
The thiol group can be used to functionalize surfaces, such as gold nanoparticles, for creating advanced biosensors and targeted delivery vehicles.