Fmoc-Nalpha-methyl-L-valine

Product Overview

Fmoc-Nalpha-methyl-L-valine is a specialized, non-natural amino acid derivative featuring an Nα-methyl group and a fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound is essential in solid-phase peptide synthesis (SPPS), where the Fmoc group enables orthogonal deprotection strategies under mild basic conditions. Its stereochemistry and steric profile make it particularly valuable for enhancing metabolic stability and conformational rigidity in bioactive peptides.

Specifications

Industrial Applications

This advanced building block serves as a critical intermediate in the synthesis of complex therapeutic peptides and modified amino acid architectures. It is notably employed in the preparation of cytotoxic agents such as Monomethyl Auristatin E (MMAE) derivatives—key components in antibody-drug conjugates (ADCs) for targeted oncology therapies. Beyond oncology, Fmoc-Nalpha-methyl-L-valine contributes to the development of peptidomimetics designed for improved pharmacokinetic profiles, including enhanced protease resistance and membrane permeability.

• Ideal for introducing N-methylation to modulate peptide backbone conformation
• Compatible with standard Fmoc-SPPS protocols
• Supports the synthesis of high-value pharmaceutical intermediates
• Enables structure-activity relationship (SAR) studies in drug discovery

Stored in a cool, dry, and well-ventilated area with containers tightly sealed to maintain stability and purity. Supplied in 25 kg drums or customized packaging per client specifications.