Copovidone VA64: A Superior Pharmaceutical Excipient
Discover the versatility of Copovidone VA64, a key ingredient for advanced pharmaceutical and cosmetic formulations.
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Copovidone VA64
Copovidone VA64 is a synthetic random copolymer of N-vinylpyrrolidone and vinyl acetate, widely recognized for its excellent performance in pharmaceutical and cosmetic applications. It serves as a crucial component in enhancing drug delivery and product formulation.
- Discover the benefits of using copovidone VA64 as a tablet binder for direct compression, significantly improving tablet hardness and reducing friability.
- Explore how copovidone VA64 acts as an effective film-former in cosmetic products, providing excellent hair-fixing properties with reduced hygroscopicity.
- Learn about copovidone VA64's role in hot melt extrusion for creating amorphous solid dispersions, thereby enhancing the dissolution of poorly soluble drugs.
- Understand the advantages of copovidone VA64 over traditional povidone, including greater plasticity, lower hygroscopicity, and improved film-forming capabilities for moisture barrier coatings.
Key Product Advantages
Enhanced Tablet Properties
Copovidone VA64 contributes to superior tablet characteristics, offering excellent binding, elasticity, and hardness, making it ideal for direct compression and wet granulation, especially in high-humidity markets.
Improved Drug Solubilization
As a matrix former, copovidone VA64 is instrumental in developing amorphous solid dispersions, a critical technique for boosting the solubility and bioavailability of poorly water-soluble active pharmaceutical ingredients.
Cosmetic Formulation Versatility
In the cosmetics industry, copovidone VA64 functions effectively as a film-former and hair-fixing agent, with its film properties being influenced by the vinyl acetate content, making it suitable for hair sprays and lotions.
Key Applications
Pharmaceutical Manufacturing
Utilized as a tablet binder for direct compression and wet granulation, and as a matrix former for controlled-release formulations, leveraging its binding and solubility enhancement properties.
Cosmetic Products
Functions as a film-former and hair-fixing agent in hair sprays, lotions, and other styling products, offering good hold and reduced hygroscopicity.
Adhesives and Coatings
Serves as a viscosity-enhancing agent, protecting colloid for printing inks, and as a binder in various coating applications, demonstrating its broad utility.
Controlled Release Systems
Its properties make it an ideal polymer matrix for solid dispersions/solutions via hot melt extrusion, facilitating the controlled release of active pharmaceutical ingredients.