High-Purity Fmoc-O1Pen-OH: A Versatile PEG Linker for Peptide Synthesis and Bioconjugation
Discover Fmoc-O1Pen-OH, a critical PEG-based linker from NINGBO INNO PHARMCHEM CO.,LTD., essential for advanced peptide synthesis and bioconjugation. Learn about its structure, purity, and applications.
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Fmoc-O1Pen-OH
As a leading manufacturer and supplier of fine chemical intermediates in China, NINGBO INNO PHARMCHEM CO.,LTD. offers Fmoc-O1Pen-OH (CAS 260367-12-2). This high-purity compound (>98%) features a polyethylene glycol (PEG) spacer with an Fmoc-protected amine and a terminal carboxylic acid group, making it an indispensable tool for researchers and product formulators.
- High Purity (>98%): Ensures reliable and reproducible results in demanding applications like peptide synthesis and bioconjugation.
- Versatile Functional Groups: The Fmoc-protected amine and carboxylic acid allow for selective conjugation via deprotection or amide bond formation, respectively.
- Hydrophilic PEG Spacer: Enhances solubility in aqueous solutions, crucial for many biological applications.
- Trusted Chemical Manufacturer: Source your Fmoc-O1Pen-OH from NINGBO INNO PHARMCHEM CO.,LTD., a reputable supplier committed to quality and consistency for your research and development projects.
Key Advantages of Using Our Fmoc-O1Pen-OH
Enhanced Solubility and Biocompatibility
The PEG spacer in Fmoc-O1Pen-OH significantly improves its solubility in aqueous environments, which is critical for many biological and pharmaceutical applications. This makes it an excellent choice for bioconjugation strategies and as a building block in drug delivery systems, offering superior performance compared to less soluble alternatives.
Controlled Reactivity for Complex Syntheses
Fmoc-O1Pen-OH allows for precise control over conjugation reactions. The Fmoc group can be readily removed under mild basic conditions to reveal a primary amine for subsequent coupling, while the carboxylic acid can be activated for amide bond formation with amines. This dual functionality makes it a versatile component for assembling complex molecules, including peptides and protein conjugates.
Reliable Sourcing from a Leading Supplier
As a dedicated supplier of high-quality fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. ensures that our Fmoc-O1Pen-OH meets stringent purity standards. Our commitment to quality control and supply chain stability means you can rely on us for consistent product availability and performance, making us your preferred manufacturer for essential chemical building blocks.
Applications of Fmoc-O1Pen-OH in Modern Chemistry
Peptide Synthesis
Fmoc-O1Pen-OH serves as an important modified amino acid derivative in solid-phase peptide synthesis (SPPS). Its incorporation allows for the introduction of a flexible PEG linker, enhancing the properties of synthesized peptides and enabling advanced research in therapeutic peptides and peptide-based materials.
Bioconjugation Chemistry
This linker is highly valued in bioconjugation for linking biomolecules such as proteins, antibodies, or nucleic acids. Its ability to form stable amide bonds and its desirable physicochemical properties make it ideal for developing targeted therapeutics, diagnostic agents, and research tools.
Antibody-Drug Conjugates (ADCs)
In the development of ADCs, Fmoc-O1Pen-OH can function as a crucial linker component. It helps to attach cytotoxic payloads to antibodies, facilitating targeted drug delivery to cancer cells. Our reliable supply chain as a manufacturer ensures you can purchase this critical component for your ADC projects.
PROTAC Synthesis
Fmoc-O1Pen-OH is also utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). As a linker, it connects the target-binding ligand to the E3 ligase-binding ligand, playing a key role in the efficacy and functionality of these innovative therapeutic molecules.