High-Purity Fmoc-Ser(tBu)-OH: Essential Amino Acid Derivative for Advanced Peptide Synthesis
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Fmoc-Ser(tBu)-OH
Fmoc-Ser(tBu)-OH is a crucial protected amino acid derivative indispensable for modern peptide synthesis, particularly in solid-phase peptide synthesis (SPPS). Its structure combines the Fmoc (9-fluorenylmethoxycarbonyl) group for N-terminal protection, removable under basic conditions, with a tert-butyl (tBu) group protecting the serine side chain, which is stable to bases but readily cleaved by acidic conditions. This orthogonal protection strategy is key to achieving precise, step-by-step peptide assembly with high coupling efficiency and minimal side reactions.
- Leveraging the Fmoc group for peptide synthesis: The Fmoc group provides reliable N-terminal protection, ensuring controlled peptide chain elongation during SPPS.
- Utilizing the tert-butyl protection strategy: The tBu group on the serine hydroxyl side chain offers stability during basic deprotection steps, crucial for complex peptide sequences.
- Enabling precise peptide assembly: The orthogonal deprotection capabilities of Fmoc-Ser(tBu)-OH facilitate controlled synthesis, critical for drug discovery applications.
- Ensuring high coupling efficiency in SPPS: Researchers rely on this derivative for its consistent performance in building complex peptide structures.
Key Advantages
High Purity Guaranteed
Achieve superior results with our Fmoc-Ser(tBu)-OH, boasting a purity of ≥98%, vital for reliable peptide synthesis and drug development.
Orthogonal Protection Strategy
The combination of Fmoc and tBu protecting groups allows for selective deprotection, minimizing side reactions and enhancing peptide fidelity.
Versatile Research Tool
This amino acid derivative is fundamental in chemical biology, enabling studies of protein interactions and enzyme mechanisms.
Key Applications
Peptide Synthesis
As a protected amino acid derivative, it is central to the precise construction of peptides in both research and pharmaceutical settings.
Drug Discovery
Its high purity and reliable deprotection make it essential for synthesizing novel peptide-based therapeutics.
Chemical Biology
Facilitates studies on protein-protein interactions and enzyme mechanisms by enabling the synthesis of targeted peptide sequences.
Biotechnology
Supports the development of new biomaterials and therapeutic agents, contributing to advancements in biotech manufacturing.