Understanding 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide: A Potent and Selective HDAC6 Inhibitor
Explore the biochemical and therapeutic potential of ACY-738, a leading HDAC6 inhibitor. Discover its applications in drug discovery and research, from neurological disorders to cancer therapeutics.
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2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
As a reliable supplier in China, we offer ACY-738, a highly potent and selective inhibitor of Histone Deacetylase 6 (HDAC6). With an IC50 of 1.7 nM, this compound is a valuable tool for researchers exploring the therapeutic potential of HDAC6 inhibition. Its applications span across drug discovery for neurological diseases, inflammatory conditions, and oncology, making it a crucial component in advancing scientific understanding and therapeutic development.
- Discover the therapeutic potential of ACY-738 in neurological research, focusing on its ability to influence α-tubulin acetylation and potentially ameliorate conditions like peripheral neuropathy.
- Leverage ACY-738 for drug discovery targeting inflammatory diseases, as studies indicate its role in attenuating the severity of certain autoimmune conditions.
- Explore ACY-738's mechanism of action as a selective HDAC6 inhibitor for advancing cancer research and developing novel anti-cancer therapies.
- Integrate ACY-738 into your drug discovery pipeline, benefiting from its oral bioavailability and established efficacy in preclinical models for various therapeutic areas.
Advantages Offered
High Potency and Selectivity
ACY-738 exhibits high potency and selectivity as an HDAC6 inhibitor, making it a precise tool for targeted research and drug development, as evidenced by its low IC50 values.
Therapeutic Potential in vivo
The compound's efficacy in preclinical models showcases its therapeutic potential in vivo, demonstrating promise for treating conditions ranging from neurological disorders to inflammatory diseases.
Versatile Research Applications
Utilize ACY-738 in various research settings, from basic science to preclinical drug screening, to advance understanding of HDAC6's role in cellular processes and disease progression.
Key Applications
HDAC6 Inhibition Studies
Conduct detailed investigations into the biological effects of HDAC6 inhibition, utilizing ACY-738 as a precise chemical probe.
Neurological Disorder Research
Explore the potential of ACY-738 in models of peripheral neuropathy and other neurological conditions, leveraging its ability to affect protein acetylation.
Inflammatory Disease Therapeutics
Investigate ACY-738's impact on inflammatory pathways and its potential as a therapeutic agent for autoimmune and inflammatory diseases.
Oncology Drug Development
Utilize ACY-738 in cancer research to understand the role of HDAC6 in tumor progression and to develop novel targeted therapies.