N,N'-Dimethylallylurea

Basic Chemical Information

Chinese Name: N,N'-Dimethylpropyleneurea (1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone)

English Name: N,N'-Dimethylpropyleneurea

CAS No.: 7226-23-5

Chinese Synonyms: DMPU; N,N'-Dimethylpropyleneurea; 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone; 1,3-Dimethyl-2-oxohexahydropyrimidine; N,N'-Dimethyltrimethyleneurea

English Synonyms: 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone; 1,3-Dimethyl-2-oxohexahydropyrimidine; N,N'-Dimethyltrimethyleneurea; Tetrahydro-1,3-dimethyl-2(1H)-pyrimidinone

Physical and Chemical Properties

Formula: C6H12N2O | Molecular Weight: 128.17 g/mol | Boiling Point: 246.5 °C at atmospheric pressure; 146 °C at 44 mmHg (~5.86 kPa) | Relative Density: d25/25 = 1.064 | Refractive Index: nD20 = 1.488–1.490 | Flash Point: 121 °C | Solubility: Fully miscible with water; soluble in chloroform, ethyl acetate, toluene, and most common organic solvents. Stability: Stable at ambient temperature and pressure, but exhibits strong hygroscopicity. Store protected from light and moisture. Reacts readily with strong oxidizers; thermal decomposition may release nitrogen oxides and carbon monoxide.

Product Specifications

Core Applications

• Polar Aprotic Solvent (Primary Use: HMPA Replacement): DMPU is an exceptional strong-polarity, high-boiling-point aprotic solvent. Its physicochemical properties and solvation/coordinating capabilities closely mirror those of hexamethylphosphoramide (HMPA). Given that HMPA is classified as a highly toxic carcinogen, DMPU—which has passed toxicological screening showing no mutagenicity and offers enhanced safety—has emerged as the premier green alternative and perfect drop-in replacement for HMPA in the chemical industry.

• High-Efficiency Organic Synthesis Medium: Functions as an outstanding co-solvent and ligand in modern organic synthesis, widely applied across highly reactive systems. It significantly accelerates nucleophilic substitution, alkylation (delivering exceptional Z-selectivity in enolate alkylations), and cyclization condensation reactions. Furthermore, it markedly boosts both yield and reaction rates when employing strong bases (e.g., LDA, n-BuLi) and highly active nucleophiles.

• Pharmaceutical & Pesticide Intermediate Synthesis: In the pharmaceutical sector, DMPU is frequently specified as a high-efficiency solvent for peptide synthesis. It is also extensively used in the synthesis and purification of antibiotics, complex active pharmaceutical ingredients (APIs), and specialty agrochemicals, effectively overcoming steric hindrance and low solubility challenges to provide an exceptionally stable and efficient reaction environment.

• Polymer Materials & Electronics Industry: Leveraging its high dielectric constant (up to 36.1) and superior thermal stability, DMPU serves as a critical solvent in the polymerization and spinning processes of specialty engineering plastics like polyarylamides. Additionally, it is commonly utilized as a functional additive in advanced battery electrolyte formulations and specialized coating recipes to enhance conductivity and film-forming properties.

Direct-from-Factory Source & Proprietary Continuous Flow Technology

As a direct-source manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. operates proprietary in-house designed tubular continuous flow reactor systems. Compared to traditional batch kettle processes, our continuous flow microchannel technology enables seamless liquid-to-liquid conversion, guaranteeing exceptional batch-to-batch consistency and inherent process safety. We are dedicated to delivering premium-grade peptide synthesis solvents and perfect drop-in alternatives to HMPA. We welcome trading companies and end-users to establish long-term strategic partnerships to create shared value.