4-Nitrobenzenesulfonyl Chloride (CAS 98-74-8): A Key Reagent in Synthesis
4-Nitrobenzenesulfonyl chloride, known by its CAS number 98-74-8, is a chemical compound widely recognized for its utility as a fine chemical intermediate. Its specific physical form and chemical reactivity make it a key reagent, particularly in the field of peptide synthesis. This article provides an overview of its appearance, its primary applications, and emphasizes the critical safety considerations that accompany its use, offering insights for those looking to source this compound from manufacturers like NINGBO INNO PHARMCHEM CO.,LTD.
Appearance and Chemical Identity
The compound typically manifests as a yellow to brown powder. With the molecular formula C6H4ClNO4S and a molecular weight of 221.62 g/mol, it belongs to the class of aromatic sulfonyl chlorides. Its melting point is generally cited in the range of 75-81°C. The structure features a sulfonyl chloride group (-SO2Cl) attached to a nitro-substituted benzene ring, which dictates its chemical behavior and applications. The purity of the compound, often specified at 98% or higher, is a critical factor for its effective use in precise chemical reactions. Reliable manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., ensure these quality standards are met.
Applications in Peptide Synthesis and Research
The primary application driving the demand for 4-Nitrobenzenesulfonyl chloride is its role in peptide synthesis. It is used to create N-nosyl protected amino acids. The nosyl group is a protecting group for the amine functionality of amino acids, which is essential for controlled peptide chain elongation. This protection strategy is vital in complex peptide synthesis, particularly for pharmaceuticals and biochemical research. Beyond this, the compound also finds use as a versatile intermediate in various other organic synthesis procedures, contributing to the creation of diverse chemical structures. For those interested in peptide synthesis materials, this compound is a fundamental building block.
Safety and Handling Best Practices
Due to its chemical nature, 4-Nitrobenzenesulfonyl chloride is classified as corrosive and requires careful handling. Users must wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety glasses or a face shield, and protective clothing to prevent contact with skin, eyes, and clothing. It is advisable to work with this chemical in a well-ventilated area or under a fume hood to avoid inhalation of dust. Promptly washing any affected skin areas with copious amounts of water is crucial in case of exposure. Proper storage in a cool, dry place, away from moisture and incompatible substances, is also recommended. Consulting the Safety Data Sheet (SDS) provided by the supplier, like NINGBO INNO PHARMCHEM CO.,LTD., is essential for detailed safety guidance.
In summary, 4-Nitrobenzenesulfonyl chloride (CAS 98-74-8) is a valuable fine chemical intermediate with critical applications in peptide synthesis. Its handling demands strict adherence to safety protocols, and sourcing from reputable manufacturers ensures quality and reliability for essential research and production needs.
Appearance and Chemical Identity
The compound typically manifests as a yellow to brown powder. With the molecular formula C6H4ClNO4S and a molecular weight of 221.62 g/mol, it belongs to the class of aromatic sulfonyl chlorides. Its melting point is generally cited in the range of 75-81°C. The structure features a sulfonyl chloride group (-SO2Cl) attached to a nitro-substituted benzene ring, which dictates its chemical behavior and applications. The purity of the compound, often specified at 98% or higher, is a critical factor for its effective use in precise chemical reactions. Reliable manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., ensure these quality standards are met.
Applications in Peptide Synthesis and Research
The primary application driving the demand for 4-Nitrobenzenesulfonyl chloride is its role in peptide synthesis. It is used to create N-nosyl protected amino acids. The nosyl group is a protecting group for the amine functionality of amino acids, which is essential for controlled peptide chain elongation. This protection strategy is vital in complex peptide synthesis, particularly for pharmaceuticals and biochemical research. Beyond this, the compound also finds use as a versatile intermediate in various other organic synthesis procedures, contributing to the creation of diverse chemical structures. For those interested in peptide synthesis materials, this compound is a fundamental building block.
Safety and Handling Best Practices
Due to its chemical nature, 4-Nitrobenzenesulfonyl chloride is classified as corrosive and requires careful handling. Users must wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety glasses or a face shield, and protective clothing to prevent contact with skin, eyes, and clothing. It is advisable to work with this chemical in a well-ventilated area or under a fume hood to avoid inhalation of dust. Promptly washing any affected skin areas with copious amounts of water is crucial in case of exposure. Proper storage in a cool, dry place, away from moisture and incompatible substances, is also recommended. Consulting the Safety Data Sheet (SDS) provided by the supplier, like NINGBO INNO PHARMCHEM CO.,LTD., is essential for detailed safety guidance.
In summary, 4-Nitrobenzenesulfonyl chloride (CAS 98-74-8) is a valuable fine chemical intermediate with critical applications in peptide synthesis. Its handling demands strict adherence to safety protocols, and sourcing from reputable manufacturers ensures quality and reliability for essential research and production needs.
Perspectives & Insights
Chem Catalyst Pro
“The nosyl group is a protecting group for the amine functionality of amino acids, which is essential for controlled peptide chain elongation.”
Agile Thinker 7
“This protection strategy is vital in complex peptide synthesis, particularly for pharmaceuticals and biochemical research.”
Logic Spark 24
“Beyond this, the compound also finds use as a versatile intermediate in various other organic synthesis procedures, contributing to the creation of diverse chemical structures.”