Mastering 4-Nitrobenzenesulfonyl Chloride: Synthesis, Safety & Applications
4-Nitrobenzenesulfonyl chloride, identified by CAS number 98-74-8, is a significant chemical compound with widespread use in organic synthesis. As a key fine chemical intermediate, it plays a vital role in various industrial and research applications. This article delves into the properties, synthesis, and critical safety considerations for handling this substance.
Chemical Properties and Synthesis
4-Nitrobenzenesulfonyl chloride is typically presented as a yellow to brown powder. Its molecular formula is C6H4ClNO4S, with a molecular weight of approximately 221.62 g/mol. The compound's melting point generally falls within the range of 75-81°C. Understanding these basic properties is crucial for its effective use and storage. Synthetically, it is often prepared through the chlorosulfonation of nitrobenzene. The purity of the compound is a key factor, with specifications often exceeding 98%, ensuring its suitability for demanding chemical reactions.
Applications in Peptide Synthesis and Beyond
One of the primary applications for 4-Nitrobenzenesulfonyl chloride is in the field of peptide synthesis. It is used to prepare N-Nosyl-α-amino acids, which are essential for certain peptide coupling procedures. This application highlights its importance in the pharmaceutical and biotechnology sectors for creating complex peptides. Beyond peptide synthesis, this compound also serves as a versatile building block in a broader range of organic synthesis reactions, contributing to the development of various fine chemicals and specialty compounds. Manufacturers in China, like NINGBO INNO PHARMCHEM CO.,LTD., are key suppliers for this important chemical intermediate.
Safety and Handling Precautions
Handling 4-Nitrobenzenesulfonyl chloride requires strict adherence to safety protocols due to its corrosive nature. Hazard symbols typically indicate that it can cause severe skin burns and eye damage. Therefore, appropriate personal protective equipment (PPE) is mandatory. This includes chemical-resistant gloves, safety goggles or a face shield, and protective clothing. Work should be conducted in a well-ventilated area or under a fume hood to avoid inhalation of dust or vapors. In case of contact, immediate rinsing with plenty of water is necessary. Storage should be in a cool, dry place, away from incompatible materials. When considering to buy 4-Nitrobenzenesulfonyl chloride, it's vital to consult the Safety Data Sheet (SDS) for comprehensive handling and emergency procedures. NINGBO INNO PHARMCHEM CO.,LTD. prioritizes safety in its operations and product information.
In summary, 4-Nitrobenzenesulfonyl chloride is a valuable chemical reagent with significant applications, particularly in peptide synthesis. Its effective and safe utilization relies on a thorough understanding of its properties and adherence to strict handling guidelines, provided by reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD.
Chemical Properties and Synthesis
4-Nitrobenzenesulfonyl chloride is typically presented as a yellow to brown powder. Its molecular formula is C6H4ClNO4S, with a molecular weight of approximately 221.62 g/mol. The compound's melting point generally falls within the range of 75-81°C. Understanding these basic properties is crucial for its effective use and storage. Synthetically, it is often prepared through the chlorosulfonation of nitrobenzene. The purity of the compound is a key factor, with specifications often exceeding 98%, ensuring its suitability for demanding chemical reactions.
Applications in Peptide Synthesis and Beyond
One of the primary applications for 4-Nitrobenzenesulfonyl chloride is in the field of peptide synthesis. It is used to prepare N-Nosyl-α-amino acids, which are essential for certain peptide coupling procedures. This application highlights its importance in the pharmaceutical and biotechnology sectors for creating complex peptides. Beyond peptide synthesis, this compound also serves as a versatile building block in a broader range of organic synthesis reactions, contributing to the development of various fine chemicals and specialty compounds. Manufacturers in China, like NINGBO INNO PHARMCHEM CO.,LTD., are key suppliers for this important chemical intermediate.
Safety and Handling Precautions
Handling 4-Nitrobenzenesulfonyl chloride requires strict adherence to safety protocols due to its corrosive nature. Hazard symbols typically indicate that it can cause severe skin burns and eye damage. Therefore, appropriate personal protective equipment (PPE) is mandatory. This includes chemical-resistant gloves, safety goggles or a face shield, and protective clothing. Work should be conducted in a well-ventilated area or under a fume hood to avoid inhalation of dust or vapors. In case of contact, immediate rinsing with plenty of water is necessary. Storage should be in a cool, dry place, away from incompatible materials. When considering to buy 4-Nitrobenzenesulfonyl chloride, it's vital to consult the Safety Data Sheet (SDS) for comprehensive handling and emergency procedures. NINGBO INNO PHARMCHEM CO.,LTD. prioritizes safety in its operations and product information.
In summary, 4-Nitrobenzenesulfonyl chloride is a valuable chemical reagent with significant applications, particularly in peptide synthesis. Its effective and safe utilization relies on a thorough understanding of its properties and adherence to strict handling guidelines, provided by reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD.
Perspectives & Insights
Data Seeker X
“When considering to buy 4-Nitrobenzenesulfonyl chloride, it's vital to consult the Safety Data Sheet (SDS) for comprehensive handling and emergency procedures.”
Chem Reader AI
“In summary, 4-Nitrobenzenesulfonyl chloride is a valuable chemical reagent with significant applications, particularly in peptide synthesis.”
Agile Vision 2025
“Its effective and safe utilization relies on a thorough understanding of its properties and adherence to strict handling guidelines, provided by reliable suppliers like NINGBO INNO PHARMCHEM CO.”