The Role of 4-Nitrobenzenesulfonyl Chloride in Modern Synthesis
4-Nitrobenzenesulfonyl chloride, bearing the CAS number 98-74-8, is a cornerstone in the architecture of modern organic and peptide synthesis. Its unique chemical structure and reactivity make it an indispensable tool for chemists. This article aims to shed light on its functional role in advanced synthetic methodologies, its physical and chemical properties, and the advantages of sourcing it from reliable manufacturers, such as those in China, to support the buy 4-Nitrobenzenesulfonyl chloride online market.
Properties and Reactivity
Typically appearing as a yellow to brown powder, 4-Nitrobenzenesulfonyl chloride (C6H4ClNO4S) is characterized by a molecular weight of 221.62 g/mol and a melting point generally between 75-81°C. The presence of the sulfonyl chloride moiety (-SO2Cl) renders it highly electrophilic, enabling it to readily react with nucleophiles. This reactivity is precisely what makes it valuable in synthetic chemistry. It can be used to introduce the nitrobenzenesulfonyl group, often referred to as the nosyl group, into molecules. This protective or activating group can be crucial in multi-step syntheses, particularly in the intricate field of peptide synthesis where precise control over functional groups is paramount.
Applications in Peptide Synthesis
Within the specialized field of peptide synthesis, 4-Nitrobenzenesulfonyl chloride is instrumental. It is employed to create N-nosylated amino acids. The nosyl group serves as a protecting group for the amino terminus of amino acids during peptide bond formation. Its stability under certain conditions and its ability to be selectively removed later in the synthesis are key advantages. This makes it a preferred reagent for researchers and manufacturers in the life sciences and pharmaceutical industries who are focused on producing high-quality peptides. The demand for such specialized reagents drives the market for compounds like 4-Nitrobenzenesulfonyl chloride from manufacturers in China.
Sourcing and Safety Considerations
When seeking to procure 4-Nitrobenzenesulfonyl chloride, engaging with reputable manufacturers and suppliers is essential. Companies like NINGBO INNO PHARMCHEM CO.,LTD. offer high-purity grades of this compound, ensuring consistency and reliability for critical applications. It is important to note that 4-Nitrobenzenesulfonyl chloride is classified as corrosive. Therefore, rigorous safety measures must be implemented during handling and storage. This includes the use of personal protective equipment (gloves, eye protection, lab coats) and working in a well-ventilated environment. Understanding the specific hazards and precautions outlined in the Safety Data Sheet (SDS) is non-negotiable for safe laboratory practices. NINGBO INNO PHARMCHEM CO.,LTD. ensures that all necessary safety information is readily available.
In conclusion, 4-Nitrobenzenesulfonyl chloride (CAS 98-74-8) is a pivotal compound in modern chemistry. Its contributions to peptide synthesis and broader organic transformations are significant, underscoring the importance of reliable sourcing and safe handling practices, as championed by leading chemical manufacturers.
Properties and Reactivity
Typically appearing as a yellow to brown powder, 4-Nitrobenzenesulfonyl chloride (C6H4ClNO4S) is characterized by a molecular weight of 221.62 g/mol and a melting point generally between 75-81°C. The presence of the sulfonyl chloride moiety (-SO2Cl) renders it highly electrophilic, enabling it to readily react with nucleophiles. This reactivity is precisely what makes it valuable in synthetic chemistry. It can be used to introduce the nitrobenzenesulfonyl group, often referred to as the nosyl group, into molecules. This protective or activating group can be crucial in multi-step syntheses, particularly in the intricate field of peptide synthesis where precise control over functional groups is paramount.
Applications in Peptide Synthesis
Within the specialized field of peptide synthesis, 4-Nitrobenzenesulfonyl chloride is instrumental. It is employed to create N-nosylated amino acids. The nosyl group serves as a protecting group for the amino terminus of amino acids during peptide bond formation. Its stability under certain conditions and its ability to be selectively removed later in the synthesis are key advantages. This makes it a preferred reagent for researchers and manufacturers in the life sciences and pharmaceutical industries who are focused on producing high-quality peptides. The demand for such specialized reagents drives the market for compounds like 4-Nitrobenzenesulfonyl chloride from manufacturers in China.
Sourcing and Safety Considerations
When seeking to procure 4-Nitrobenzenesulfonyl chloride, engaging with reputable manufacturers and suppliers is essential. Companies like NINGBO INNO PHARMCHEM CO.,LTD. offer high-purity grades of this compound, ensuring consistency and reliability for critical applications. It is important to note that 4-Nitrobenzenesulfonyl chloride is classified as corrosive. Therefore, rigorous safety measures must be implemented during handling and storage. This includes the use of personal protective equipment (gloves, eye protection, lab coats) and working in a well-ventilated environment. Understanding the specific hazards and precautions outlined in the Safety Data Sheet (SDS) is non-negotiable for safe laboratory practices. NINGBO INNO PHARMCHEM CO.,LTD. ensures that all necessary safety information is readily available.
In conclusion, 4-Nitrobenzenesulfonyl chloride (CAS 98-74-8) is a pivotal compound in modern chemistry. Its contributions to peptide synthesis and broader organic transformations are significant, underscoring the importance of reliable sourcing and safe handling practices, as championed by leading chemical manufacturers.
Perspectives & Insights
Nano Explorer 01
“This makes it a preferred reagent for researchers and manufacturers in the life sciences and pharmaceutical industries who are focused on producing high-quality peptides.”
Data Catalyst One
“The demand for such specialized reagents drives the market for compounds like 4-Nitrobenzenesulfonyl chloride from manufacturers in China.”
Chem Thinker Labs
“Sourcing and Safety Considerations When seeking to procure 4-Nitrobenzenesulfonyl chloride, engaging with reputable manufacturers and suppliers is essential.”