In the dynamic fields of biotechnology and pharmaceutical research, precise molecular manipulation is paramount. At the forefront of these advancements lies the science of bioconjugation, a technique that allows scientists to chemically link biomolecules, creating novel therapeutic agents, diagnostic tools, and research probes. Among the critical reagents facilitating these complex procedures, N-Succinimidyl 11-(maleimido)undecanoate stands out for its unique bifunctional nature and high specificity.

Understanding the utility of N-Succinimidyl 11-(maleimido)undecanoate (CAS 87981-04-2) is key for any researcher involved in creating sophisticated biomolecular constructs. This compound acts as a versatile linker, bridging two distinct molecular entities through specific chemical reactions. Its structure incorporates two highly reactive functional groups: a maleimide moiety and an N-hydroxysuccinimide (NHS) ester. This duality allows for sequential or simultaneous conjugation, offering unparalleled flexibility in experimental design.

The maleimide group is renowned for its selective reaction with free sulfhydryl (thiol) groups found in cysteine residues of proteins and peptides. This reaction proceeds rapidly under mild conditions, forming a stable thioether bond. This specificity is crucial, minimizing unwanted side reactions and ensuring that the conjugation occurs precisely where intended. For procurement, seeking a reliable supplier of N-Succinimidyl 11-(maleimido)undecanoate in China can ensure access to high-quality material at competitive prices.

Complementing the maleimide functionality is the NHS ester. This group is highly reactive towards primary amines, commonly found in the lysine residues of proteins and peptides, as well as in amine-modified nucleic acids or small molecules. The reaction between the NHS ester and an amine forms a stable amide bond, releasing N-hydroxysuccinimide as a byproduct. This amine reactivity further broadens the application scope of N-Succinimidyl 11-(maleimido)undecanoate, making it an adaptable tool for a wide array of bioconjugation strategies.

The long, ten-carbon aliphatic chain separating the two functional groups offers several advantages. It provides adequate spacing, which can be critical for maintaining the activity and accessibility of the conjugated biomolecules. This linker also imparts a degree of hydrophobicity, potentially influencing the solubility and stability of the final conjugate. Researchers often inquire about the N-Succinimidyl 11-(maleimido)undecanoate price to budget for their projects, and sourcing from reputable manufacturers is key to obtaining both quality and cost-effectiveness.

The primary applications for N-Succinimidyl 11-(maleimido)undecanoate are extensive and impactful. In the realm of targeted therapeutics, it is a cornerstone for synthesizing Antibody-Drug Conjugates (ADCs). By linking cytotoxic drug payloads to specific antibodies that target cancer cells, ADCs offer a more precise approach to chemotherapy, minimizing systemic toxicity. Similarly, in diagnostics, this linker is vital for creating enzyme-linked immunosorbent assays (ELISAs), fluorescent probes, and other biosensors where specific molecular recognition and labeling are required.

For those looking to buy N-Succinimidyl 11-(maleimido)undecanoate online, it is essential to choose suppliers that can guarantee purity, consistent batch-to-batch quality, and reliable delivery. As a leading chemical provider, we are dedicated to supporting scientific innovation by offering this critical reagent. We understand the importance of a robust supply chain for ongoing research and development activities, ensuring that you can purchase the quantities you need, when you need them.

In summary, N-Succinimidyl 11-(maleimido)undecanoate is more than just a chemical compound; it is an enabler of advanced molecular engineering. Its specific thiol-maleimide and amine-NHS ester chemistries, coupled with its versatile linker arm, make it indispensable for modern bioconjugation. Whether you are developing novel cancer therapies, designing sensitive diagnostic kits, or conducting fundamental research, securing a high-quality supply of this reagent is a crucial step towards achieving groundbreaking results.