The intricate world of life sciences relies heavily on tools that allow for the precise modification and interrogation of biological molecules. N-Succinimidyl 11-(maleimido)undecanoate (CAS 87981-04-2) is one such indispensable reagent, serving as a critical crosslinker that enables researchers to connect diverse biomolecules with high specificity. As a key component in numerous research protocols, understanding its capabilities and sourcing it reliably is crucial for scientific progress.

At its core, N-Succinimidyl 11-(maleimido)undecanoate is a bifunctional linker. This means it possesses two distinct reactive ends designed to bind to different molecular targets. The first end, a maleimide group, is exceptionally reactive towards sulfhydryl (thiol) groups. This selective reaction, forming a stable thioether linkage, is fundamental for conjugating the linker to cysteine residues in proteins or peptides, or to any molecule that has been engineered to contain a thiol group. This specificity ensures that modifications occur at desired sites, minimizing interference with other functional groups.

The second functional group is an N-hydroxysuccinimide (NHS) ester. This moiety is highly effective in reacting with primary amines, which are abundant in biological molecules, particularly the lysine residues in proteins. The reaction between the NHS ester and an amine results in the formation of a stable amide bond, releasing N-hydroxysuccinimide. This dual reactivity – thiol-specific and amine-reactive – makes N-Succinimidyl 11-(maleimido)undecanoate a powerful tool for a wide range of applications in life science research.

Researchers often inquire about purchasing this chemical due to its broad utility. Whether it’s for protein labeling with fluorescent dyes or enzymes, immobilizing biomolecules onto surfaces for biosensors, or constructing complex molecular architectures, this linker provides a reliable solution. As a leading N-Succinimidyl 11-(maleimido)undecanoate supplier in China, we are committed to providing researchers with the high-purity reagents they need to drive innovation.

Key applications where N-Succinimidyl 11-(maleimido)undecanoate excels include:

  • Protein Labeling: Attaching fluorescent tags, enzymes, or biotin to proteins for detection and analysis in techniques like Western blotting, ELISA, and microscopy.
  • Antibody Conjugation: Linking antibodies to various effectors, such as toxins for ADCs, enzymes for assays, or nanoparticles for targeted delivery. The thiol-maleimide chemistry is particularly useful when dealing with cysteine-engineered antibodies for controlled conjugation.
  • Surface Immobilization: Covalently attaching proteins, peptides, or nucleic acids to solid supports (e.g., microplates, biosensor chips) for creating diagnostic devices or studying molecular interactions.
  • Peptide Synthesis and Modification: Incorporating specialized functionalities into synthetic peptides or modifying existing ones to enhance stability, targeting, or drug-like properties.

The accessibility and affordability of this reagent are crucial for researchers working with limited budgets. Therefore, identifying a trustworthy supplier of N-Succinimidyl 11-(maleimido)undecanoate that offers competitive pricing is a significant advantage. Our commitment to quality ensures that when you buy N-Succinimidyl 11-(maleimido)undecanoate from us, you receive a product that meets rigorous specifications, enabling reproducible and reliable experimental outcomes.

In conclusion, N-Succinimidyl 11-(maleimido)undecanoate is a versatile and essential tool for life science researchers. Its unique chemical properties allow for precise and stable bioconjugation, opening doors to advancements in diagnostics, therapeutics, and fundamental biological studies. By sourcing this critical reagent from a reliable manufacturer, scientists can confidently pursue their research objectives, confident in the quality and availability of their supplies.