The efficacy of pharmaceutical products hinges on the quality of their constituent ingredients, particularly critical intermediates like 4-Phenylbutan-2-amine (CAS: 22374-89-6). As a cornerstone in the synthesis of Labetalol, an essential antihypertensive drug, understanding its physical and chemical properties, along with stringent purity requirements, is crucial for any pharmaceutical formulator or manufacturer. This article provides an in-depth look at what makes 4-Phenylbutan-2-amine a vital component and how to best procure it.

Chemical and Physical Characteristics:

4-Phenylbutan-2-amine typically presents as a colorless liquid. Its molecular formula, C10H15N, and a molecular weight of 149.233 indicate a relatively straightforward yet potent chemical structure. Key properties vital for its application include:

  • Appearance: Colorless liquid, ensuring ease of handling and integration into liquid-phase reactions.
  • Purity: A minimum assay of ≥99.0% by both Gas Chromatography (GC) and titration is essential. This high level of purity minimizes unwanted side reactions and ensures the quality of the final pharmaceutical product.
  • Moisture Content: Keeping moisture levels below 0.5% is critical, as water can interfere with sensitive synthesis steps.
  • Boiling Point: 221.5±0.0 °C at 760 mmHg signifies its stability under elevated temperatures, a common condition in chemical synthesis.
  • Melting Point: A low melting point of -50ºC ensures it remains in a liquid state across a wide operational temperature range.

The Importance of Purity in Pharmaceutical Synthesis:

In the pharmaceutical industry, even trace impurities can have significant consequences. For intermediates like 4-Phenylbutan-2-amine, deviations from specified purity levels can lead to:

  • Reduced yield of the final drug substance (Labetalol).
  • Formation of undesired byproducts that require costly removal.
  • Potential impact on the drug's safety and efficacy profile.

Therefore, when you plan to buy 4-Phenylbutan-2-amine, it is imperative to partner with a manufacturer that not only meets but consistently exceeds these purity benchmarks. Sourcing from a reputable supplier in China, such as NINGBO INNO PHARMCHEM CO.,LTD., ensures you receive a product that meets the exacting demands of pharmaceutical development and large-scale production.

Procurement and Supply Chain Excellence:

Securing a reliable supply of 4-Phenylbutan-2-amine requires due diligence. Engage with manufacturers who provide transparent documentation, including Certificates of Analysis, and possess robust quality management systems. For those seeking to purchase this intermediate, focusing on suppliers with established export capabilities and a commitment to customer service will facilitate a smoother acquisition process. NINGBO INNO PHARMCHEM CO.,LTD. stands ready to serve as your trusted supplier, offering high-quality 4-Phenylbutan-2-amine at competitive prices, backed by extensive industry experience.