The quest for novel therapeutics often relies on specialized chemical building blocks that enable the synthesis of complex molecules with targeted biological activities. 5-Bromoindole-2-carboxylic acid (CAS: 7254-19-5) is one such crucial compound, widely recognized in the pharmaceutical and chemical industries for its versatility and potential. This article explores the diverse applications of this indole derivative, highlighting its significance in drug discovery and development, and provides insights for procurement professionals seeking a reliable supplier.

The Role of 5-Bromoindole-2-carboxylic Acid in Pharmaceuticals

As a key pharmaceutical intermediate, 5-Bromoindole-2-carboxylic acid serves as a starting material for a broad spectrum of biologically active compounds. Its indole backbone is a common motif in many natural products and synthetic drugs, known for their diverse pharmacological effects. The bromine substituent and the carboxylic acid group offer specific sites for chemical modification, allowing chemists to construct intricate molecular architectures with precision. This makes it an invaluable component in the synthesis of potential treatments for various diseases.

Key Applications in Research and Development

The applications of 5-Bromoindole-2-carboxylic acid are extensive and continue to expand:

  • Anti-Cancer Agents: This compound has been utilized in the synthesis of tubulin polymerization inhibitors, which are critical for preventing cancer cell proliferation. Its derivatives are also being investigated for their efficacy against various cancer cell lines.
  • Anti-Inflammatory Drugs: Research has shown its use in developing dual PPARγ/δ agonists, compounds that play a role in regulating inflammation and metabolic processes.
  • Enzyme Inhibitors: It is employed in the synthesis of indoleamine 2,3-dioxygenase (IDO) inhibitors, which are of interest for immune-oncology applications.
  • Arthritis Treatment: Studies have leveraged this intermediate for the discovery of indole inhibitors of MMP-13, targeting arthritic diseases.
  • Diagnostic Tools: The compound can be functionalized to create chemical probes for studying biological pathways and receptors, enhancing diagnostic capabilities.

When looking to buy 5-Bromoindole-2-carboxylic acid, it is essential to consider its CAS number (7254-19-5) and purity, ensuring it meets the stringent requirements of pharmaceutical R&D. Procurement managers often seek out manufacturers who can guarantee consistent quality and a stable supply chain.

Sourcing Strategies for R&D Professionals

Identifying a dependable manufacturer and supplier for 5-Bromoindole-2-carboxylic acid is crucial for any research project. Global chemical suppliers, particularly those with a strong presence in manufacturing, offer this compound. When evaluating potential suppliers, consider factors such as:

  • Product Purity and Analytical Data: Ensure the supplier provides comprehensive Certificates of Analysis (CoA).
  • Production Capacity: For projects requiring larger quantities, a manufacturer with scalable production is vital.
  • Regulatory Compliance: For pharmaceutical applications, adherence to quality standards is paramount.
  • Pricing and Lead Times: Competitive pricing and reliable delivery schedules are important for budget and project planning.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to being your preferred supplier for high-quality chemical intermediates like 5-Bromoindole-2-carboxylic acid. Contact us to discuss your sourcing needs and receive a competitive quote.