At NINGBO INNO PHARMCHEM CO.,LTD., we are proud to support pharmaceutical companies in achieving their manufacturing goals. This hypothetical case study outlines how a leading pharmaceutical manufacturer successfully improved its production efficiency and tablet quality by integrating Silicified Microcrystalline Cellulose (SMCC) into its formulations.

The company, a well-established producer of oral solid dosage forms, was facing challenges with its primary tablet formulation for a widely prescribed medication. Specifically, they experienced inconsistent powder flow, leading to significant tablet weight variation and increased reject rates during the compression stage. The existing excipient, while functional, required the addition of high levels of lubricants to prevent sticking to the tablet press tooling, which in turn negatively impacted the tablet disintegration time.

Seeking a solution, the manufacturer evaluated several advanced excipients, including SMCC supplied by NINGBO INNO PHARMCHEM CO.,LTD. After rigorous testing and formulation optimization, they found that replacing their current microcrystalline cellulose with SMCC offered a transformative improvement. The improved flowability of SMCC significantly reduced tablet weight variation, leading to a dramatic decrease in reject rates by over 60%. This directly translated to higher batch yields and improved throughput on their tablet presses.

Furthermore, the enhanced compressibility of SMCC allowed the manufacturer to reduce the amount of external lubricant needed by approximately 40%. This not only simplified the formulation but also restored the tablet's disintegration profile to optimal levels, ensuring better drug absorption. The improved tablet hardness achieved with SMCC also meant fewer damaged tablets during packaging and transit, contributing to overall product integrity and reduced waste.

The integration of SMCC also facilitated faster formulation development and easier scale-up. The excipient's robust performance characteristics made the process less sensitive to minor variations in processing parameters, providing greater confidence in batch-to-batch consistency. This case study highlights the practical, tangible benefits of using high-quality SMCC. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing excipients like SMCC that enable our clients to achieve superior manufacturing outcomes, optimize their processes, and deliver high-quality medications to patients.