For scientists engaged in pharmaceutical research and development, understanding the chemical nuances of key intermediates is vital. 2,3-Dihydrobenzofuran-5-carbaldehyde (CAS 55745-70-5) stands out as a particularly important compound, serving as a critical building block in the synthesis of various pharmaceuticals, notably the sleep aid Ramelteon.

The molecular structure of 2,3-Dihydrobenzofuran-5-carbaldehyde, C9H8O2, features a dihydrobenzofuran core fused with an aldehyde group at the 5-position. This aldehyde functionality is highly reactive and serves as a versatile handle for further chemical modifications. Its reactivity profile makes it an ideal candidate for carbon-carbon bond formation, condensation reactions, and other transformations essential in multi-step organic synthesis.

Researchers often seek this intermediate for its potential to introduce specific structural motifs into drug candidates. The benzofuran scaffold itself is present in numerous biologically active molecules, suggesting that derivatives of 2,3-Dihydrobenzofuran-5-carbaldehyde could possess a range of pharmacological activities. The synthesis of Ramelteon, for instance, leverages this intermediate to build the core structure of the drug, highlighting its direct contribution to therapeutic advancements.

When sourcing this compound for research or large-scale manufacturing, scientists typically look for high purity, often specified as ≥98.0% by Gas Chromatography (GC). This purity is critical to avoid side reactions, ensure predictable yields, and meet the stringent quality requirements of the pharmaceutical industry. Manufacturers often provide detailed specifications on parameters such as boiling point (around 277.5 °C at 760 mmHg) and density (approximately 1.2 g/cm³), which are indicative of product quality and stability.

The availability of this compound from reliable manufacturers and suppliers in China, often with competitive pricing, further supports its widespread use. For those looking to buy 2,3-Dihydrobenzofuran-5-carbaldehyde, engaging with suppliers who can provide consistent quality and technical support is recommended. This ensures that your synthetic pathways are robust and that the resulting pharmaceutical products meet the highest standards. Exploring quotes from various suppliers can also help in securing cost-effective solutions for your R&D or production needs.