In the intricate landscape of pharmaceutical manufacturing, the selection of appropriate chemical intermediates is a cornerstone of successful drug development and production. One such vital compound is 1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone, identified by its CAS number 1378387-81-5. This specialized organic molecule serves as a critical building block, facilitating the synthesis of important therapeutic agents.

Understanding 1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone

This fluorene derivative, CAS 1378387-81-5, is characterized by its complex structure, featuring a bromine substituent, difluoro substitution at the 9-position of the fluorene ring, and a chloroacetyl group. Typically appearing as a white to light yellow powder or crystal, its high purity, often specified as ≥99.0%, is essential for its use in the demanding pharmaceutical sector. This purity level ensures that downstream reactions proceed with high yields and minimal by-product formation, a critical factor for manufacturers aiming for cost-efficiency and regulatory compliance.

Applications in API Manufacturing

The primary application of 1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone is as an intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs), notably remipavir. Its unique chemical architecture makes it a versatile starting material for constructing complex molecular scaffolds that are characteristic of modern pharmaceuticals. For procurement managers and R&D scientists, understanding the role of this intermediate is key to optimizing synthetic routes and ensuring a stable supply of critical drug precursors. Working with a reliable manufacturer that understands these applications is paramount.

Why Choose a Dedicated Manufacturer?

When sourcing intermediates like CAS 1378387-81-5, partnering with a dedicated chemical manufacturer offers distinct advantages. Manufacturers, such as NINGBO INNO PHARMCHEM CO.,LTD., maintain rigorous quality control throughout the production process, from raw materials to the final product. This ensures batch-to-batch consistency, a crucial element for pharmaceutical production. Furthermore, direct sourcing often translates to more competitive pricing and direct access to technical expertise. We are committed to being a premier supplier in China, providing high-quality 1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone to support your ongoing research and manufacturing needs. We welcome all inquiries for this vital chemical.

Key Considerations for Procurement

When evaluating suppliers for 1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone, consider the following:

  • Purity and Documentation: Always demand a Certificate of Analysis (CoA) confirming purity levels.
  • Manufacturing Expertise: Look for manufacturers with a proven track record in complex organic synthesis, particularly with fluorinated compounds.
  • Scalability: Ensure the manufacturer can support your needs from R&D quantities to bulk commercial orders.
  • Supply Chain Reliability: A stable and consistent supply is critical for production timelines.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to meeting these exacting standards. We encourage potential buyers to contact us to discuss their specific requirements for 1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone, including requesting a quote or sample.