In the dynamic field of fine chemicals and pharmaceutical intermediates, understanding the properties and applications of key compounds is vital for both researchers and procurement specialists. 4-Phenylbutan-2-amine (CAS: 22374-89-6) is one such compound, recognized primarily for its essential role in the synthesis of Labetalol, a critical drug used to manage hypertension. This article provides a comprehensive look at 4-Phenylbutan-2-amine, covering its synthesis, applications, and essential considerations for sourcing, particularly from manufacturers in China.

Chemical Profile and Synthesis:

4-Phenylbutan-2-amine is an organic chemical characterized by its appearance as a colorless liquid. Its molecular formula is C10H15N, with a molecular weight of 149.233. Key physical and chemical properties include a boiling point of 221.5±0.0 °C at 760 mmHg and a low melting point of -50ºC. Crucially for its use as a pharmaceutical intermediate, it boasts a high assay of ≥99.0% by both GC and titration, with moisture content typically kept at or below 0.5%. The synthesis of such high-purity intermediates often involves sophisticated organic chemistry techniques to ensure minimal impurities, making the expertise of the manufacturer paramount.

Applications in the Pharmaceutical Industry:

The primary application of 4-Phenylbutan-2-amine is as a critical intermediate in the production of Labetalol (CAS: 36894-69-6). Labetalol is a highly effective antihypertensive agent that works by blocking both alpha and beta adrenergic receptors. The reliable availability of high-purity 4-Phenylbutan-2-amine is therefore essential for pharmaceutical companies manufacturing Labetalol. Its structure also suggests potential utility in the synthesis of other complex organic molecules or novel pharmaceutical compounds, making it a valuable asset in drug discovery and development.

Sourcing from China: A Strategic Choice:

For international buyers looking to purchase 4-Phenylbutan-2-amine, China presents a robust and competitive market. Chinese manufacturers have become leading global suppliers due to their advanced production capabilities, strict quality control measures, and cost-effective operations. When seeking to buy 4-Phenylbutan-2-amine, it is advisable to:

  • Identify reputable manufacturers: Look for companies with a proven history in producing pharmaceutical intermediates.
  • Verify quality standards: Ensure the supplier can provide detailed Certificates of Analysis confirming purity and specifications.
  • Assess production capacity: Confirm they can meet your volume requirements consistently.
  • Compare pricing: Obtain quotes from several reliable suppliers to ensure competitive pricing.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier of 4-Phenylbutan-2-amine in China, committed to delivering exceptional quality and service to our global clientele. We invite you to contact us to discuss your needs and explore how our high-purity intermediates can support your pharmaceutical manufacturing and R&D objectives.