Angiogenesis, the formation of new blood vessels, is a critical biological process implicated in numerous physiological and pathological conditions, most notably cancer. The study and manipulation of angiogenesis pathways are central to developing novel therapies. In this context, Fumagillin (CAS 23110-15-8) stands out as a key chemical entity. This article delves into the anti-angiogenic mechanisms of Fumagillin and provides insights into how researchers and procurement managers can effectively source this compound from global manufacturers.

Fumagillin: A Potent Inhibitor of Angiogenesis

Fumagillin's efficacy as an anti-angiogenic agent stems from its ability to inhibit methionine aminopeptidase-2 (MetAP-2). MetAP2 is a crucial enzyme involved in various cellular functions, including protein synthesis and cell proliferation. By specifically targeting and inactivating MetAP2, Fumagillin disrupts the signaling pathways that promote endothelial cell migration, proliferation, and survival – processes fundamental to the formation of new blood vessels. This targeted action makes Fumagillin an invaluable tool for researchers investigating diseases driven by aberrant angiogenesis, such as solid tumors.

For scientists focusing on cancer therapy development, understanding how to buy Fumagillin for preclinical and in-vitro studies is crucial. Its known effects on endothelial cells make it a standard reagent in laboratories exploring anti-cancer drug mechanisms.

Applications Beyond Angiogenesis

While its anti-angiogenic properties are most prominent, Fumagillin also exhibits antiprotozoal activity, showing efficacy against certain parasitic infections. This dual nature broadens its research scope, making it a versatile compound for various life science investigations. As a pharmaceutical intermediate, its chemical structure can also be a starting point for synthesizing other biologically active molecules.

Sourcing Strategies for Fumagillin (CAS 23110-15-8)

Procuring high-quality Fumagillin requires a strategic approach, especially when considering bulk purchases. Researchers and procurement specialists often look for 'Fumagillin supplier China' due to the competitive pricing and manufacturing capabilities available. When you need to purchase Fumagillin, several factors should guide your selection:

  • Quality Assurance: Always prioritize suppliers who provide comprehensive Certificates of Analysis (CoA) detailing purity (often specified as ≥90% HPLC), identity, and other relevant specifications.
  • Technical Specifications: Confirm that the product meets your research needs, paying attention to molecular weight (458.54 g/mol), formula (C26H34O7), and appearance (typically a white powder).
  • Supplier Reputation: Research the supplier's track record, customer reviews, and commitment to quality. Engaging with established manufacturers can ensure reliability.
  • Pricing and Lead Times: Obtain quotes for 'methionine aminopeptidase-2 inhibitor price' to compare and ensure you are getting value for your investment. Understand lead times for delivery, especially for larger quantities.

For bulk orders, directly contacting manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. can streamline the procurement process. Their role as a manufacturer ensures direct access to product information and competitive terms for those looking to buy Fumagillin bulk quantity.

In summary, Fumagillin (CAS 23110-15-8) is indispensable for advancing research in angiogenesis and related therapeutic areas. By adopting a thoughtful sourcing strategy and partnering with reliable chemical suppliers, research institutions and pharmaceutical companies can ensure they have access to this critical research chemical.