In the intricate world of pharmaceutical development, the availability of high-quality intermediates is paramount. These chemical building blocks are essential for synthesizing active pharmaceutical ingredients (APIs) and exploring new therapeutic modalities. Fumagillin, identified by CAS number 23110-15-8, is one such compound that holds significant promise and utility in this domain. This guide is designed for procurement managers and R&D scientists seeking to understand Fumagillin's role and efficiently buy Fumagillin as a key pharmaceutical intermediate.

Fumagillin: A Versatile Pharmaceutical Intermediate

Fumagillin (C26H34O7, MW: 458.54 g/mol) is primarily known for its potent anti-angiogenic properties, attributed to its inhibition of methionine aminopeptidase-2 (MetAP-2). This biological activity has opened avenues for its exploration in cancer therapy and other diseases where controlling blood vessel formation is critical. However, beyond its direct therapeutic potential, Fumagillin's complex molecular structure and reactive functional groups make it an attractive pharmaceutical intermediate for chemists engaged in drug synthesis.

As a chemical intermediate, Fumagillin can be modified through various chemical reactions to create novel compounds with potentially enhanced or different biological activities. Its availability in high purity (often specified as ≥90% HPLC) is crucial for ensuring the success and reproducibility of downstream synthesis processes. When you are looking to purchase Fumagillin for these purposes, sourcing from reputable manufacturers is key.

Applications in Drug Discovery and Synthesis

Researchers often utilize Fumagillin in the early stages of drug discovery. Its known biological targets and mechanisms provide a solid foundation for developing new drug candidates. Specifically:

  • Oncology: Its role in inhibiting angiogenesis makes it a target for research in anti-cancer drug development.
  • Inflammatory Diseases: Angiogenesis is also implicated in chronic inflammation, offering another area where Fumagillin-derived compounds could be explored.
  • Synthesis of Analogues: Medicinal chemists may use Fumagillin as a starting material to synthesize analogues with improved pharmacological profiles, such as better bioavailability, reduced toxicity, or altered target specificity.

When inquiring about the 'methionine aminopeptidase-2 inhibitor price' for synthesis purposes, it's important to consider the volume and purity requirements, as these will influence the overall cost.

Efficient Sourcing from Manufacturers

Securing a reliable supply of Fumagillin is critical for pharmaceutical companies and research institutions. When searching for a 'Fumagillin supplier China', prioritize those with robust quality control systems and a proven track record in producing pharmaceutical intermediates. Manufacturers often provide detailed product specifications, including CAS number, molecular formula, and purity, along with safety data sheets (SDS) and Certificates of Analysis (CoA).

For those requiring larger quantities, exploring options to buy Fumagillin bulk quantity directly from manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. is advisable. This approach typically leads to better pricing and ensures a more consistent supply chain. Engage with potential suppliers early to discuss your specific needs, obtain quotes, and understand their production capabilities and lead times.

In conclusion, Fumagillin (CAS 23110-15-8) is a valuable compound that serves both as a research tool and a critical pharmaceutical intermediate. By understanding its properties and employing a strategic sourcing approach, organizations can ensure they have access to this essential chemical for their drug development pipelines.