Fumagillin, identified by its CAS number 23110-15-8, is a compound that has significantly impacted our understanding of biological processes, particularly angiogenesis and cellular metabolism. Its utility spans across various research disciplines, from oncology to fundamental biochemistry. For procurement professionals and research scientists, understanding Fumagillin's value and how to source it efficiently is crucial for enabling groundbreaking work. This article provides a procurement-focused perspective on Fumagillin, detailing its scientific relevance and sourcing strategies.

Fumagillin's Scientific Significance: A Dual Action

The scientific community recognizes Fumagillin primarily for two key activities: its potent anti-angiogenic properties and its role as an inhibitor of methionine aminopeptidase-2 (MetAP-2). Angiogenesis, the formation of new blood vessels, is vital for tissue development but is also a critical factor in the growth and metastasis of tumors. By inhibiting MetAP2, Fumagillin disrupts the endothelial cell functions necessary for angiogenesis, thereby offering a therapeutic target for various cancers. Researchers frequently search for 'anti-angiogenic agent' when seeking compounds like Fumagillin.

Beyond its anti-angiogenic effects, Fumagillin also demonstrates antiprotozoal activity, proving effective against certain parasitic infections. This broad spectrum of biological activity makes it a compound of interest for a wide range of research applications. The chemical itself, with the formula C26H34O7 and molecular weight of 458.54 g/mol, is typically supplied as a white powder with high purity, often exceeding 90% by HPLC. This level of purity is non-negotiable when aiming to buy Fumagillin for reproducible scientific outcomes.

Key Research Areas Utilizing Fumagillin

Fumagillin is instrumental in several research domains:

  • Oncology: Its anti-angiogenic mechanism makes it a focal point in developing treatments that target tumor vascularization.
  • Vascular Biology: Scientists use Fumagillin to study endothelial cell proliferation, migration, and survival, furthering our understanding of vascular diseases.
  • Biochemical Assays: As a specific enzyme inhibitor, it is employed to elucidate the functions of MetAP-2 in cellular pathways.
  • Drug Development: It can serve as a scaffold or intermediate for synthesizing novel therapeutic agents.

When considering the 'methionine aminopeptidase-2 inhibitor price', procurement managers should evaluate the overall value proposition, including quality, consistency, and supplier reliability.

Procurement Strategies for Fumagillin (CAS 23110-15-8)

For organizations needing to purchase Fumagillin, especially in substantial quantities, a well-defined procurement strategy is essential. Partnering with a reputable 'Fumagillin supplier China' can offer cost advantages and access to advanced manufacturing capabilities. Key considerations for procurement include:

  • Supplier Vetting: Ensure the supplier has a strong quality management system, providing Certificates of Analysis (CoA) and Safety Data Sheets (SDS).
  • Bulk Purchase Advantages: To buy Fumagillin bulk quantity, direct engagement with manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. is recommended to negotiate favorable pricing and secure a consistent supply chain.
  • Technical Specifications: Confirm that the product meets your specific research or synthesis needs regarding purity, appearance, and formulation.
  • Lead Time Management: Understand the supplier's production and delivery timelines, especially for critical research projects.

By approaching the procurement of Fumagillin strategically, research institutions and companies can ensure they have a reliable source of this scientifically impactful compound, thereby facilitating advancements in their respective fields.