Fumagillin, a compound characterized by CAS number 23110-15-8, is a noteworthy molecule in the field of chemical research and development. With its distinct chemical structure (C26H34O7) and significant biological activity, it has garnered attention for its anti-angiogenic and antiprotozoal effects. This article serves as a guide for researchers and procurement professionals seeking to understand Fumagillin's properties, its applications, and how to source it effectively from trusted suppliers.

Chemical and Biological Profile of Fumagillin

Fumagillin, a complex organic compound with a molecular weight of 458.54 g/mol, typically presents as a white powder. Its primary mode of action is the inhibition of methionine aminopeptidase-2 (MetAP-2). This enzyme is essential for cellular protein synthesis and plays a role in various signaling pathways. By inhibiting MetAP2, Fumagillin exerts cytostatic effects, particularly on endothelial cells, which are critical for angiogenesis – the process of forming new blood vessels. This mechanism makes Fumagillin a key subject in studies related to cancer and other angiogenesis-dependent diseases.

Researchers looking to buy Fumagillin for experimental purposes need to ensure they obtain a product with reliable purity, typically specified as ≥90% by HPLC. The consistent quality of this chemical is vital for reproducible research outcomes.

Key Applications in Scientific Research

Fumagillin's unique properties lend themselves to a variety of research applications:

  • Cancer Research: Its ability to inhibit angiogenesis makes it a target compound for developing anti-cancer therapies that aim to starve tumors.
  • Vascular Biology Studies: Fumagillin is used to investigate the mechanisms controlling endothelial cell proliferation and migration, contributing to a deeper understanding of vascular health and disease.
  • Biochemical Research: As a specific enzyme inhibitor, it aids in studying the functions of methionine aminopeptidase-2 and related biochemical pathways.
  • Drug Discovery: The compound can also serve as a valuable starting material or intermediate for synthesizing novel drug candidates with modified properties.

When inquiring about the 'methionine aminopeptidase-2 inhibitor price', researchers should factor in the purity and quantity required for their specific experimental setup.

Sourcing Fumagillin (CAS 23110-15-8) Effectively

To ensure a dependable supply of Fumagillin, it is advisable to partner with established chemical suppliers and manufacturers. When you aim to purchase Fumagillin, especially in bulk, looking for a 'Fumagillin supplier China' can provide access to competitive pricing and manufacturing expertise. Reputable suppliers typically provide:

  • Certificates of Analysis (CoA): Detailing product purity, identification, and specifications.
  • Safety Data Sheets (SDS): Providing crucial handling and safety information.
  • Technical Data: Including molecular weight, formula, and appearance.
  • Bulk Ordering Capabilities: For those looking to buy Fumagillin bulk quantity for larger research projects or early-stage manufacturing.

Engaging with manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. can offer direct benefits, ensuring a streamlined procurement process and reliable product quality for your research needs.

In summary, Fumagillin (CAS 23110-15-8) is a significant chemical compound with diverse applications in scientific research. By understanding its properties and sourcing it from reputable suppliers, researchers can confidently utilize this molecule to advance their studies.