Fumagillin, identified by its CAS number 23110-15-8, is a fascinating compound with significant implications in biomedical research and pharmaceutical development. As a leading supplier of specialized chemicals, understanding the needs of researchers and product developers is paramount. This article aims to provide a comprehensive overview of Fumagillin, from its chemical properties and biological activities to its applications and how to effectively source it from reliable manufacturers, particularly those based in China.

Understanding Fumagillin: Chemical Profile and Biological Activity

Fumagillin, with the molecular formula C26H34O7 and a molecular weight of 458.54 g/mol, is recognized for its potent anti-angiogenic and antiprotozoal properties. Its primary mechanism of action involves the covalent binding and inhibition of methionine aminopeptidase-2 (MetAP-2). This enzyme plays a critical role in cellular processes, and its inhibition by Fumagillin leads to cytostatic effects, particularly against endothelial cells, which are essential for angiogenesis – the formation of new blood vessels.

The compound appears as a white powder, and while specific physical states can vary slightly depending on purity and storage, it is generally stable under recommended conditions. Researchers often seek high-purity Fumagillin to ensure accurate and reproducible experimental results. When you are looking to buy Fumagillin CAS 23110-15-8, purity is a key specification to consider.

Key Applications in Research and Development

The unique properties of Fumagillin make it a valuable asset in several scientific fields:

  • Angiogenesis Inhibition: Fumagillin is widely used in cancer research to inhibit tumor angiogenesis. By preventing the growth of new blood vessels that feed tumors, it offers a potential therapeutic avenue. Researchers often query for 'anti-angiogenic agent for research' when seeking this compound.
  • Vascular Biology: Its direct effects on endothelial cell proliferation make Fumagillin a crucial tool for studying the intricate processes of vascular development and disease.
  • Pharmaceutical Intermediates: Fumagillin can serve as a building block or intermediate in the synthesis of more complex pharmaceutical compounds. Its specific structure and reactivity are advantageous for medicinal chemists. Companies looking to develop new drugs may inquire about its availability as a 'pharmaceutical intermediate'.
  • Antiprotozoal Research: Historically, Fumagillin has shown activity against certain protozoan parasites, making it relevant for research in veterinary medicine and the study of infectious diseases.

Sourcing Fumagillin: Partnering with Reliable Suppliers

For researchers and businesses, securing a consistent and high-quality supply of Fumagillin is essential. When you are searching to buy Fumagillin, partnering with a reputable Fumagillin supplier China can offer significant advantages, including competitive pricing and scalability. Manufacturers specializing in fine chemicals and pharmaceutical intermediates are well-equipped to meet diverse order requirements, from small research quantities to bulk industrial volumes.

When evaluating potential suppliers, consider factors such as:

  • Purity and Quality Control: Ensure the supplier provides a Certificate of Analysis (CoA) detailing purity levels, typically assessed by HPLC.
  • Supply Chain Reliability: A consistent supply chain is critical for ongoing research and production.
  • Technical Support: Access to technical data and support can be invaluable.
  • Pricing and Payment Terms: Compare quotes for methionine aminopeptidase-2 inhibitor price to ensure cost-effectiveness.

For those looking to purchase Fumagillin bulk quantity, direct engagement with manufacturers is often the most efficient approach. This allows for direct negotiation on price and potential customization of packaging or specifications. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to providing high-quality chemicals and supporting the global scientific community with essential research materials.

In conclusion, Fumagillin (CAS 23110-15-8) remains a cornerstone compound for research in angiogenesis and related fields. By understanding its properties and partnering with reliable suppliers, researchers can effectively leverage this potent molecule to drive scientific discovery and pharmaceutical innovation.