Hyponatremia, a condition defined by abnormally low sodium levels in the blood, affects a significant number of patients with chronic illnesses. Understanding the underlying causes and effective treatment strategies is vital for patient outcomes. Tolvaptan, with CAS number 150683-30-0, has emerged as a key therapeutic agent in this domain, offering a targeted approach to correcting serum sodium levels.

Tolvaptan functions as a selective vasopressin V2 receptor antagonist. This means it specifically blocks the action of vasopressin, a hormone that regulates water balance by influencing water reabsorption in the kidneys. By inhibiting this process, Tolvaptan promotes the excretion of free water, thereby increasing serum sodium concentration. This mechanism is crucial for patients suffering from hyponatremia caused by conditions like heart failure, cirrhosis, and SIADH, where fluid overload contributes to low sodium levels. Knowing how to treat hyponatremia with Tolvaptan involves leveraging this specific pharmacological action.

The implementation of Tolvaptan in patient care is guided by strict Tolvaptan safety precautions. Due to the potential risk of osmotic demyelination syndrome (ODS) if sodium levels rise too quickly, the initiation and titration of Tolvaptan therapy require close medical supervision, ideally within a hospital setting. This careful monitoring ensures that the rate of serum sodium correction is appropriate, minimizing the risk of serious neurological complications. Additionally, physicians must be aware of potential adverse effects, such as liver injury, and manage treatment duration accordingly.

For manufacturers and researchers, obtaining Tolvaptan from a reliable Tolvaptan API supplier in China is essential for ensuring product quality and consistency. As a crucial pharmaceutical intermediate, its purity and adherence to specifications are paramount. The chemical properties, including its molecular formula C26H25ClN2O3 and appearance as a white powder, are standard references for quality assessment. By prioritizing safety and sourcing from reputable suppliers, the medical and pharmaceutical communities can effectively utilize Tolvaptan to improve patient lives.