Tolvaptan, identified by its CAS number 150683-30-0, is a non-peptide, selective antagonist of the arginine vasopressin V2 receptor. This chemical compound has garnered significant attention in the pharmaceutical industry due to its critical role in managing certain types of hyponatremia. Understanding its chemical and physical properties is the first step for any researcher or manufacturer looking to utilize this potent molecule.

The molecular formula for Tolvaptan is C26H25ClN2O3, with a molecular weight of approximately 448.94. Typically presented as a white to tan powder, it exhibits a melting point in the range of 219-222°C, with some sources indicating a slightly higher range up to 230-240°C. Its solubility in DMSO is notable, making it amenable to various laboratory procedures and formulations. These detailed specifications are crucial for professionals working with the compound, ensuring accurate handling and experimental design.

The therapeutic application of Tolvaptan primarily revolves around its ability to selectively increase serum sodium concentration by promoting aquaresis (excretion of free water). This makes it an effective treatment for patients suffering from hypervolemic and euvolemic hyponatremia, often seen in conditions such as congestive heart failure, liver cirrhosis, and SIADH. The drug's ability to enhance the kidney's capacity to excrete water without significantly affecting electrolyte excretion is a key advantage. This targeted action is what professionals look for when seeking to treat hyponatremia with Tolvaptan.

For pharmaceutical manufacturers, sourcing Tolvaptan as a pharmaceutical intermediate or API requires a focus on purity and reliability. A dependable Tolvaptan API supplier in China ensures that the product meets the stringent standards required for drug development and production. The development of comprehensive safety protocols, informed by the Tolvaptan safety precautions, is equally vital. These precautions, which include careful monitoring of serum sodium levels and awareness of potential liver injury, are indispensable for responsible clinical use, reinforcing the importance of diligent sourcing and application.