In the intricate world of pharmaceutical synthesis, the quality and consistency of chemical intermediates directly influence the success of drug development and manufacturing. 2-Amidinopyrimidine Hydrochloride (CAS: 138588-40-6), a key heterocyclic intermediate, plays a significant role in creating complex APIs. For R&D scientists and formulation specialists, understanding its properties and sourcing implications is crucial for optimizing synthesis pathways.

The Chemical Profile of 2-Amidinopyrimidine Hydrochloride

This compound, identified by its CAS number 138588-40-6, typically presents as a grey white powder. Its molecular formula is C5H6N4.HCl, with a molecular weight of approximately 158.59 g/mol. A critical attribute for pharmaceutical applications is its purity, which reputable manufacturers ensure is consistently high, often at 98% or above. This purity is essential to avoid side reactions and ensure the final API meets stringent regulatory standards.

Impact on Synthesis Efficiency and Quality

The structural features of 2-Amidinopyrimidine Hydrochloride make it a valuable synthon. As an intermediate for drugs like Bosentan, its reliable availability and consistent quality directly translate to:

  • Predictable Reaction Outcomes: High-purity intermediates minimize the introduction of unwanted impurities, leading to more predictable and efficient reactions. This saves time and resources in process development.
  • Improved Yields: Using well-characterized and pure starting materials like 2-Amidinopyrimidine Hydrochloride can lead to higher yields of the desired API, reducing manufacturing costs.
  • Reduced Purification Challenges: A purer starting intermediate often means less complex and costly purification steps for the final product, streamlining the overall manufacturing process.
  • Ensured API Quality: The quality of the final API is inextricably linked to the quality of its precursors. Sourcing from a trusted manufacturer of 2-Amidinopyrimidine Hydrochloride guarantees that the intermediate contributes positively to the final drug's efficacy and safety profile.

Sourcing Strategies for R&D Scientists

For scientists looking to buy 2-Amidinopyrimidine Hydrochloride for their research, several strategies are recommended:

  • Partner with Specialized Suppliers: Engaging with companies that specialize in pharmaceutical intermediates and fine chemicals, such as NINGBO INNO PHARMCHEM CO.,LTD., ensures access to expertise and quality products.
  • Request Technical Data: Always request the latest COA and MSDS. Understanding the physical and chemical properties, as well as safety handling information, is critical for laboratory work.
  • Consider Scale-Up Potential: Even for early-stage research, consider if your supplier can also provide larger quantities if the project progresses. A reliable pharmaceutical intermediate supplier can support your journey from lab bench to production scale.
  • Inquire about Pricing and Availability: Comparing the price of pyrimidine-2-carboximidamide hydrochloride from multiple established suppliers can help manage R&D budgets effectively.

By prioritizing quality and reliability when sourcing 2-Amidinopyrimidine Hydrochloride, pharmaceutical companies can significantly enhance their drug synthesis efficiency and ensure the development of high-quality APIs. We at NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to supporting your scientific endeavors with our premium pharmaceutical intermediates. Reach out to us to learn more about how we can fulfill your chemical needs.