In the realm of chemical synthesis, understanding the specific properties and applications of intermediate compounds is essential for successful product development. 4-Chlorophenacyl bromide, also known by its systematic name 2-Bromo-1-(4-chlorophenyl)ethanone and identified by CAS number 536-38-9, is a versatile compound widely utilized across various industries, particularly in pharmaceuticals and fine chemicals. This article provides a comprehensive overview of its characteristics and applications.

Chemical and Physical Properties of 4-Chlorophenacyl Bromide

4-Chlorophenacyl bromide (C8H6BrClO) is an organic compound characterized by its molecular weight of 233.49 g/mol. Its appearance is typically described as a white to pale yellow crystalline solid. Key physical properties include:

  • Melting Point: It generally melts within the range of 93-99°C.
  • Solubility: It is soluble in organic solvents such as methanol and acetone but shows limited solubility in water, consistent with its relatively non-polar aromatic structure.
  • Stability: The compound is generally stable under recommended storage conditions, typically requiring storage in a cool, dry place, often at 2-8°C, and protected from light and moisture.
  • Reactivity: The alpha-bromine atom is highly reactive, making it an excellent electrophilic site for nucleophilic substitution reactions. This reactivity is central to its utility as a synthetic intermediate. It can also act as a lachrymator, necessitating careful handling.

Applications Across Industries

The versatility of 4-Chlorophenacyl bromide makes it a valuable intermediate in several key areas:

  • Pharmaceutical Synthesis: It is extensively used in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its role as a building block for compounds like Tolvaptan underscores its importance in drug development.
  • Organic Synthesis: As a reactive building block, it is employed in a wide array of organic transformations, including the formation of carbon-carbon and carbon-heteroatom bonds. It’s crucial for introducing the 4-chlorophenacyl moiety into target molecules.
  • Agrochemicals: It also finds application in the synthesis of certain crop protection chemicals and other agricultural products.
  • Research and Development: Its predictable reactivity makes it a standard reagent in academic and industrial research labs for exploring new synthetic methodologies and discovering novel compounds.

Procurement and Handling Considerations

When purchasing 4-Chlorophenacyl bromide, it is essential to source from reputable manufacturers and suppliers. Key considerations include:

  • Purity: Always aim for high purity, typically ≥99.0%, as confirmed by a Certificate of Analysis (COA).
  • Supplier Reliability: Partner with suppliers who provide consistent quality, reliable delivery, and transparent pricing. Manufacturers in China are often a good source for cost-effective, high-quality material.
  • Safety: Due to its lachrymatory properties, proper handling with appropriate personal protective equipment (PPE) in a well-ventilated area is crucial. Always consult the Safety Data Sheet (SDS).

By understanding the properties and applications of 4-Chlorophenacyl bromide and partnering with dependable suppliers, researchers and manufacturers can effectively leverage this vital chemical intermediate for their innovative projects. Engage with trusted sources to ensure the quality and availability of this critical compound for your synthesis needs.