In the intricate world of pharmaceutical manufacturing, the selection of high-quality intermediates is crucial for the development of safe and effective drugs. One such vital compound is 4-Chlorophenacyl bromide, also known by its systematic name 2-Bromo-1-(4-chlorophenyl)ethanone, and identified by CAS number 536-38-9. This article delves into its significance, properties, and the best practices for sourcing this essential chemical.

Understanding 4-Chlorophenacyl Bromide (CAS 536-38-9)

4-Chlorophenacyl bromide is an organic compound characterized by its specific chemical structure, featuring a halogenated phenyl ring and an alpha-brominated acetyl group. This structure imbues it with a reactivity that makes it an excellent building block in complex organic synthesis. Typically appearing as a white to light yellow crystalline solid, it boasts high purity, often exceeding 98% or 99%, which is critical for pharmaceutical applications. Its molecular weight is approximately 233.49 g/mol.

Significance in Pharmaceutical Synthesis

The primary value of 4-Chlorophenacyl bromide lies in its extensive use as an intermediate in the synthesis of pharmaceuticals. It serves as a precursor for various biologically active molecules, contributing to the development of treatments for a range of conditions. Notably, it is recognized as an intermediate in the synthesis pathway of Tolvaptan, a medication used for treating hyponatremia and heart failure. Researchers and pharmaceutical companies rely on this compound to introduce specific functional groups and construct the molecular frameworks of potential drug candidates. Its consistent quality and reliable availability from manufacturers are therefore of utmost importance.

Key Applications and Research Areas

  • API Synthesis: Essential for building the molecular backbone of many Active Pharmaceutical Ingredients (APIs).
  • Drug Discovery: Utilized in medicinal chemistry for creating novel compounds with targeted biological activities.
  • Intermediate for Tolvaptan: A documented precursor in the production of this important therapeutic agent.
  • Agrochemicals: Also finds application in the synthesis of certain agricultural chemicals.
  • Biochemical Research: Employed in studies involving protein labeling and modification due to its reactive nature.

Sourcing and Purchasing Considerations

When procuring 4-Chlorophenacyl bromide, it is imperative to partner with reputable manufacturers and suppliers. For businesses seeking to buy this compound, especially in larger quantities, looking for suppliers in regions like China can offer competitive pricing and accessible supply chains. Key factors to evaluate include:

  • Purity: Always prioritize products with high purity (e.g., ≥99.0%) confirmed by a Certificate of Analysis (COA).
  • Supplier Reliability: Choose manufacturers with established quality control systems and a proven history of consistent supply.
  • Pricing and Quotes: Obtain detailed quotes for the required quantities, comparing unit prices for bulk orders.
  • Technical Support: Engage with suppliers who can provide technical specifications and support for your synthesis projects.
  • Safety and Storage: Ensure you understand the proper handling and storage requirements (typically cool, dry conditions, away from heat and light).

By focusing on these aspects, R&D scientists and procurement managers can ensure they obtain high-quality 4-Chlorophenacyl bromide, facilitating efficient and successful pharmaceutical development. Investing in a dependable supplier is an investment in the integrity and efficacy of your final pharmaceutical products.