For procurement managers in the pharmaceutical and fine chemical industries, sourcing critical intermediates like 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine (CAS 6626-40-0) is a strategic imperative. Understanding the market, quality parameters, and reliable suppliers is key to ensuring the smooth progression of research and development projects. This guide aims to provide essential information for procurement professionals looking to buy this specialized heterocyclic compound.

Understanding 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine

This compound, with the CAS number 6626-40-0, is recognized for its complex chemical structure and its crucial role as a pharmaceutical intermediate. It is particularly noted for its application in the synthesis of pyronaridine, an antimalarial drug. Its molecular formula is C13H8Cl2N2O, with a molecular weight of 279.12. Typically supplied as a pale yellow solid, its purity is a critical factor for its downstream applications. Reliable manufacturers often guarantee purity levels exceeding 95% (HPLC).

Key Considerations for Procurement: Quality and Specifications

When sourcing this intermediate, procurement managers must prioritize suppliers who can consistently deliver material meeting stringent quality specifications. Essential parameters include:

  • Purity: As mentioned, a purity of 95% or higher is generally required for effective use in pharmaceutical synthesis. Verified by HPLC analysis.
  • Physical Appearance: Consistent pale yellow solid form.
  • Storage Conditions: Information regarding proper storage, such as under an inert atmosphere (nitrogen or argon) at 2-8°C, is vital to maintain product integrity.
  • Documentation: Availability of Certificates of Analysis (CoA) and Safety Data Sheets (SDS) is non-negotiable.

Finding Reliable Suppliers and Manufacturers

The global market offers several manufacturers and suppliers of 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine. However, for cost-effectiveness and supply chain stability, many businesses look to manufacturers based in China. When evaluating potential suppliers, consider factors such as:

  • Manufacturing Capacity: Can they meet your volume requirements for both R&D and commercial scale?
  • Quality Control Processes: Do they have robust QC measures in place to ensure batch-to-batch consistency?
  • Regulatory Compliance: Are they familiar with international regulatory requirements for pharmaceutical intermediates?
  • Customer Service and Responsiveness: How quickly do they respond to inquiries and provide quotes?

Navigating Pricing and Purchasing

The price of 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine can vary based on purity, quantity, and supplier. It is advisable to obtain multiple quotes from different manufacturers to ensure competitive pricing. For R&D quantities, prices might be quoted per milligram or gram, while larger commercial orders will likely be priced per kilogram. Always inquire about bulk discounts and payment terms. When you are ready to buy, look for suppliers who offer seamless ordering processes and reliable logistics.

Conclusion

Procuring 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine requires a thorough understanding of its specifications and the supplier landscape. By partnering with experienced manufacturers and suppliers, procurement managers can secure a high-quality, cost-effective supply of this essential pharmaceutical intermediate, thereby supporting the advancement of critical drug development projects. For your next purchase, consider reputable manufacturers in China who specialize in fine chemical intermediates.