(R)-2-Methyl-CBS-oxazaborolidine
- CAS No.112022-83-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
Premium chiral intermediate used in asymmetric synthesis for major pharmaceutical APIs like Ezetimibe and Aprepitant.
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Product Overview
(R)-2-Methyl-CBS-oxazaborolidine is a highly specialized chiral boron-containing compound widely recognized in the pharmaceutical industry for its critical role in asymmetric synthesis. As a derivative of the Coreys-Bakshi-Shibata (CBS) catalyst system, this reagent facilitates enantioselective reductions, enabling the precise construction of chiral centers essential for modern drug development. Our manufacturing process ensures exceptional optical purity and chemical stability, making it an indispensable building block for the production of complex therapeutic agents.
We understand the stringent requirements of pharmaceutical synthesis. Therefore, our facility adheres to rigorous quality control standards to deliver consistent batch-to-batch performance. This product is specifically engineered to support the synthesis of high-value active pharmaceutical ingredients (APIs), ensuring that downstream processes meet regulatory compliance and efficiency targets.
Technical Specifications
Our quality assurance team verifies every parameter against strict internal standards. The following table outlines the key physical and chemical properties guaranteed for this product.
| Parameter | Specification |
|---|---|
| CAS Number | 112022-83-0 |
| Molecular Formula | C18H20BNO |
| Molecular Weight | 277.17 g/mol |
| Appearance | White to yellowish crystalline powder |
| Purity | ≥98.0% |
| Melting Point | 85-95°C |
| Density | 0.925 g/cm3 |
| Boiling Point | 377.5°C at 760 mmHg |
In addition to standard specifications, we provide comprehensive documentation including Certificates of Analysis (COA), Method Validation Reports, and Stability Data upon request. Our technical support team is available to assist with integration into your specific synthesis workflows.
Pharmaceutical Applications
This chiral intermediate serves as a key precursor in the manufacturing of several blockbuster medications. Its primary application lies in the stereoselective synthesis of compounds requiring high enantiomeric excess. Notable downstream applications include:
- Ezetimibe Synthesis: A critical intermediate in the production of this lipid-lowering agent, ensuring the correct stereochemistry for biological activity.
- Treprostinil Pathways: Utilized in the synthesis of Treprostinil and its salts, which are vital for treating pulmonary arterial hypertension.
- Aprepitant Production: Supports the creation of this neurokinin-1 receptor antagonist used in the prevention of chemotherapy-induced nausea.
By utilizing our high-purity grade, manufacturers can optimize yield and reduce purification steps, ultimately lowering the cost of goods for the final API.
Storage and Handling
To maintain optimal quality, (R)-2-Methyl-CBS-oxazaborolidine should be stored in a cool, dry, and well-ventilated area. Containers must remain tightly closed to protect against moisture and strong light, as the compound may be sensitive to hydrolysis or photodegradation over extended periods. We recommend storage temperatures consistent with standard warehouse conditions, away from incompatible materials such as strong oxidizing agents.
Packing options include 25kg cardboard drums or customized packaging solutions tailored to client logistics requirements. Our supply chain ensures secure global delivery with full traceability. For bulk orders or custom synthesis requests, please contact our sales team for a detailed quotation and lead time assessment.
