(R)-Methyl 2-Amino-2-(4-Hydroxyphenyl)Acetate
- CAS No.37763-23-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (R)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate (CAS 37763-23-8) is a critical chiral intermediate for Amoxicillin synthesis, available in bulk quantities with strict quality control.
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Product Overview
(R)-Methyl 2-Amino-2-(4-Hydroxyphenyl)Acetate, widely recognized by its CAS registry number 37763-23-8, stands as a pivotal chiral building block in the modern pharmaceutical industry. This specialized organic compound serves as an essential intermediate in the stereoselective synthesis of beta-lactam antibiotics, most notably Amoxicillin. Our manufacturing facility is dedicated to producing this high-value chemical with exceptional enantiomeric purity, ensuring that downstream pharmaceutical processes meet the rigorous standards required for global medicinal applications.
The chemical structure features a chiral center at the alpha position, which is critical for the biological activity of the final antibiotic product. Maintaining the correct (R)-configuration is paramount, as the wrong enantiomer can lead to reduced efficacy or unwanted side effects in the final drug formulation. Our advanced synthesis routes are optimized to maximize the yield of the desired isomer while minimizing impurities, providing our partners with a reliable source of this key pharmaceutical intermediate.
Key Specifications and Physical Properties
| Parameter | Specification |
|---|---|
| CAS Number | 37763-23-8 |
| Molecular Formula | C9H11NO3 |
| Molecular Weight | 181.189 g/mol |
| Appearance | White Crystalline Powder |
| Assay (Purity) | ≥99.0% |
| Specific Rotation | -146° to -156° |
| Loss on Drying | ≤0.5% |
| Boiling Point | 303.2±27.0 °C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
Industrial Applications
The primary application of (R)-Methyl 2-Amino-2-(4-Hydroxyphenyl)Acetate is in the production of semi-synthetic penicillins. It acts as a side-chain precursor that is coupled with the beta-lactam nucleus to form Amoxicillin, one of the most widely prescribed antibiotics worldwide. The high optical purity of our intermediate ensures that the final antibiotic product possesses the necessary potency and safety profile required by regulatory bodies such as the FDA and EMA.
Beyond Amoxicillin, this compound may also find utility in the research and development of other phenylglycine derivatives used in medicinal chemistry. Our technical team supports clients in optimizing their synthesis pathways, offering guidance on reaction conditions and stoichiometry to ensure efficient conversion rates during the manufacturing of active pharmaceutical ingredients (APIs).
Quality Assurance and Packaging
Quality control is the cornerstone of our operation. Every batch of (R)-Methyl 2-Amino-2-(4-Hydroxyphenyl)Acetate undergoes stringent testing using high-performance liquid chromatography (HPLC) and polarimetry to verify assay purity and specific rotation. We provide a comprehensive Certificate of Analysis (COA) with every shipment, detailing all critical quality attributes.
- Standard Packaging: 25kg fiber drums with inner polyethylene liners.
- Custom Packaging: Available upon request to suit specific logistics needs.
- Storage Conditions: Store in a cool, dry, and well-ventilated area away from direct sunlight.
- Shelf Life: 24 months when stored under recommended conditions.
We are committed to being a reliable global partner for pharmaceutical manufacturers. Our supply chain is robust, ensuring timely delivery of bulk quantities to support continuous production schedules. For inquiries regarding pricing, technical data sheets, or custom synthesis requirements, please contact our sales team for prompt assistance.
