Intermediates

(S)-2-Aminopropanamide Hydrochloride

  • CAS No.33208-99-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity chiral intermediate essential for Safinamide synthesis, offering consistent quality and reliable supply for pharmaceutical manufacturing.

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Product Technical Details

Product Overview

(S)-2-Aminopropanamide hydrochloride stands as a critical chiral building block within the modern pharmaceutical landscape. As a key intermediate, this compound plays an indispensable role in the asymmetric synthesis of advanced neurological therapeutics. Our facility specializes in the production of high-enantiomeric purity materials, ensuring that every batch meets the rigorous demands of medicinal chemistry and process development teams. We understand that consistency in chirality is paramount for downstream reaction success, which is why our manufacturing protocols prioritize strict stereochemical control.

This hydrochloride salt form offers enhanced stability and solubility characteristics compared to the free base, making it highly suitable for various synthetic transformations. The compound is meticulously processed to minimize impurities that could interfere with subsequent coupling reactions or catalytic steps. By selecting our supply, pharmaceutical manufacturers gain access to a reliable source of material that supports efficient scale-up from laboratory research to commercial production.

Technical Specifications

Quality assurance is the cornerstone of our chemical supply chain. Each lot of (S)-2-Aminopropanamide hydrochloride undergoes comprehensive analytical testing using validated methods including HPLC, polarimetry, and thermal analysis. The following table outlines the standard specification parameters that define our premium grade material:

ParameterSpecification
AppearanceWhite to off-white powder
Assay (HPLC)98.0% - 102.0%
Melting Point210 - 220°C
Specific Rotation+9° ~ +13°
Moisture Content≤0.5%
Molecular FormulaC3H9ClN2O
Molecular Weight124.569

These specifications are designed to ensure compatibility with sensitive synthetic routes. The specific rotation range confirms the high optical purity required for the synthesis of chiral drugs. Our quality control team maintains detailed records for every batch, allowing for full traceability from raw material sourcing to final packaging.

Industrial Applications

The primary application of this chemical entity is serving as a strategic intermediate in the manufacture of Safinamide. Safinamide is a significant pharmaceutical agent used in the management of Parkinson's disease, acting as a reversible monoamine oxidase B inhibitor. The integrity of the starting material directly influences the yield and purity of the final active pharmaceutical ingredient (API). Consequently, our product is utilized by process chemists who require dependable performance during amide bond formation and subsequent functional group modifications.

Beyond this specific pathway, (S)-2-Aminopropanamide hydrochloride serves as a versatile synthon in organic chemistry. It can be employed in the development of novel peptide mimetics and other nitrogen-containing heterocycles. Our technical support team is available to discuss potential use cases and provide guidance on handling procedures to maximize reaction efficiency.

Packaging and Storage

To preserve the chemical integrity of the product during transit and storage, we utilize robust packaging solutions. The standard commercial package consists of 25 kg fiber drums lined with double polyethylene bags, ensuring protection against moisture and contamination. For research-scale requirements or specific logistical needs, custom packaging configurations are available upon request. We recommend storing the material in a cool, ventilated area away from direct sunlight and strong oxidizing agents. Proper storage conditions help maintain the specified moisture content and prevent degradation over time. All shipments are accompanied by a Certificate of Analysis (COA) and relevant safety documentation to facilitate smooth customs clearance and warehouse intake.