1-(1H-Indol-6-yl)ethanone

Product Overview

1-(1H-Indol-6-yl)ethanone, commonly known as 6-Acetylindole, represents a vital structural motif in modern medicinal chemistry and fine chemical synthesis. As a specialized intermediate, this compound features an indole core substituted with an acetyl group at the sixth position, offering unique reactivity profiles for downstream derivatization. Our facility produces this material under strict Good Manufacturing Practice guidelines to ensure consistency and reliability for industrial partners seeking high-quality chemical building blocks.

Chemical Properties And Structure

The molecular structure of 1-(1H-Indol-6-yl)ethanone (CAS 81223-73-6) provides a versatile platform for constructing complex heterocyclic systems. The presence of the carbonyl functionality allows for various transformations, including reduction, oxidation, and condensation reactions, making it an invaluable building block for research and development teams. With a molecular formula of C10H9NO and a molecular weight of 159.185, this compound exhibits stable physical properties suitable for large-scale processing and storage in standard chemical environments.

Industrial Applications

In the pharmaceutical industry, indole derivatives serve as key precursors for numerous active pharmaceutical ingredients. This specific acetylindole variant is frequently utilized in the synthesis of kinase inhibitors and other therapeutic agents targeting neurological and oncological pathways. Beyond pharmaceuticals, it finds applications in agrochemical development and material science, where high-purity organic intermediates are required to maintain product performance and safety standards. The versatility of this intermediate extends to custom synthesis projects where specific substitution patterns on the indole ring are required.

Chemists value the 6-position acetyl group for its ability to participate in Friedel-Crafts reactions and other electrophilic substitutions. This makes it an ideal candidate for developing novel chemical entities during the early stages of drug discovery. Furthermore, its stability under standard laboratory conditions facilitates ease of use in various synthetic routes without requiring specialized handling equipment.

Quality Assurance And Specifications

Quality assurance is paramount in our production process. Each batch of 1-(1H-Indol-6-yl)ethanone undergoes rigorous analytical testing using High-Performance Liquid Chromatography and Nuclear Magnetic Resonance spectroscopy. We guarantee an assay purity of ≥98.0%, ensuring minimal impurities that could affect subsequent reaction yields. Comprehensive Certificates of Analysis are provided with every shipment, documenting all critical quality attributes and test results for full transparency.

Our commitment to quality extends beyond final product testing. We monitor raw materials and intermediate steps throughout the manufacturing process to prevent contamination. The production environment is controlled to minimize exposure to atmospheric contaminants, ensuring the pale-yellow to yellow-brown solid remains free from degradation. Clients can rely on our technical support team for assistance with application-specific queries and formulation guidance.

Storage And Packaging

Proper handling and storage are essential to maintain the integrity of this chemical product. We recommend storing the material in a cool, ventilated area away from direct sunlight and moisture. Our standard packaging includes 25 kg drums, though we offer flexible custom packaging solutions to meet specific logistical requirements. As a global manufacturer, we ensure secure shipping methods to deliver products safely to laboratories and production facilities worldwide.