Intermediates

1,2-Dibromo-5-Chloro-3-Fluorobenzene

  • CAS No.208186-78-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 1,2-Dibromo-5-Chloro-3-Fluorobenzene is a premium halogenated aromatic intermediate designed for complex organic synthesis and pharmaceutical research applications.

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Product Technical Details

Product Overview

1,2-Dibromo-5-Chloro-3-Fluorobenzene is a highly specialized halogenated aromatic compound that serves as a critical building block in modern organic chemistry. Manufactured under strict quality control protocols, this substance features a unique substitution pattern on the benzene ring, providing versatile reactivity for various synthetic transformations. Our facility ensures that every batch meets rigorous international standards for purity and consistency, making it an ideal choice for research laboratories and industrial-scale production environments.

This chemical entity is characterized by its stability and specific reactivity profile, attributed to the presence of multiple halogen atoms including bromine, chlorine, and fluorine. These functional groups allow chemists to perform selective substitutions and coupling reactions with high precision. As a leading global manufacturer, we prioritize safety and compliance throughout the production lifecycle, ensuring that our clients receive materials that are ready for immediate use in sensitive synthetic pathways.

Technical Specifications

The following table outlines the key physical and chemical properties of our premium grade 1,2-Dibromo-5-Chloro-3-Fluorobenzene. All parameters are verified through advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy to guarantee accuracy.

Parameter Specification
Chemical Name 1,2-Dibromo-5-Chloro-3-Fluorobenzene
CAS Number 208186-78-1
Molecular Formula C6H2Br2ClF
Molecular Weight 288.34 g/mol
Appearance Off-white to light brown crystalline powder
Purity ≥97% (Typical Batch ≥98.5%)
Melting Point 37-39°C
Boiling Point 245.3°C at 760 mmHg
Density 2.089 g/cm3
Flash Point 102.1°C

Industrial Applications

This halogenated benzene derivative is extensively utilized in the synthesis of complex organic molecules. Its primary application lies in serving as a substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. The distinct positioning of the halogen atoms allows for sequential functionalization, enabling the construction of sophisticated molecular architectures required in advanced material science and agrochemical development.

In the pharmaceutical sector, this intermediate is valuable for developing novel therapeutic candidates where specific halogen substitution patterns are required to modulate biological activity or metabolic stability. Additionally, it finds use in the creation of liquid crystals, polymers, and other specialty chemicals where precise electronic properties are essential. Our manufacturing process is optimized to minimize impurities that could interfere with downstream catalytic processes, ensuring high yields in subsequent reaction steps.

Quality Assurance and Safety

We understand that consistency is paramount in chemical manufacturing. Each production lot of 1,2-Dibromo-5-Chloro-3-Fluorobenzene undergoes comprehensive testing before release. A Certificate of Analysis (COA) is provided with every shipment, detailing the specific test results for purity, identity, and physical constants. Our quality management system adheres to international standards, ensuring traceability and reliability for our partners.

Regarding safety, this compound should be handled in accordance with standard laboratory safety procedures for halogenated organic substances. Proper personal protective equipment, including gloves and eye protection, is recommended during handling. Storage should be in a cool, dry, and well-ventilated area away from incompatible materials. We are committed to supplying not only high-quality products but also the necessary support documentation to ensure safe and compliant usage within your facility.