1,2-Difluoro-4-methyl-5-nitrobenzene
- CAS No.127371-50-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1,2-Difluoro-4-methyl-5-nitrobenzene (CAS 127371-50-0), a key fluorinated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
1,2-Difluoro-4-methyl-5-nitrobenzene is a high-value fluorinated aromatic compound widely employed as a versatile building block in complex organic synthesis. With its unique substitution pattern—featuring two ortho-fluorine atoms, a methyl group, and a nitro functionality—this molecule serves as a critical intermediate in the development of specialty chemicals, including active pharmaceutical ingredients (APIs) and crop protection agents. Our product is manufactured under stringent quality control protocols to ensure consistent performance and reliability for industrial-scale applications.
Specifications
| Molecular Formula | C₇H₅F₂NO₂ |
|---|---|
| Molecular Weight | 173.12 g/mol |
| CAS Number | 127371-50-0 |
| Appearance | Light yellow transparent liquid |
| Assay (GC) | ≥98.0% |
| Density | 1.4 ± 0.1 g/cm³ |
| Boiling Point | 224.5 ± 35.0 °C at 760 mmHg |
| Flash Point | 97.9 ± 14.2 °C |
| Refractive Index | 1.509 |
| Vapor Pressure | 0.1 ± 0.4 mmHg at 25 °C |
Industrial Applications
This fluorinated nitroaromatic compound is primarily utilized as a synthetic intermediate in multi-step organic transformations. Its electron-deficient aromatic ring, combined with strategic fluorine placement, enables selective nucleophilic aromatic substitution (SNAr), cross-coupling reactions, and reduction pathways to access diverse heterocyclic scaffolds. Key application sectors include:
- Pharmaceutical R&D for novel neurological and metabolic therapeutics
- Agrochemical innovation in next-generation herbicides and insecticides
- Materials science for liquid crystals and electronic organic semiconductors
Due to its reactivity profile, it is not intended for direct formulation but rather as a foundational component in controlled synthetic sequences.
Handling and Storage
Store in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep container tightly closed when not in use. Use appropriate personal protective equipment (PPE) during handling, including gloves and eye protection, in accordance with local safety regulations.
