1,3,5-Trifluorobenzene
- CAS No.372-38-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1,3,5-Trifluorobenzene (CAS 372-38-3) is a key fluorinated aromatic intermediate widely used in pharmaceutical and liquid crystal material synthesis.
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Product Overview
1,3,5-Trifluorobenzene is a symmetrical trifluorinated aromatic compound with the molecular formula C6H3F3 and a molecular weight of 132.08 g/mol. As a high-value fluorochemical building block, it serves as a critical intermediate in the synthesis of advanced pharmaceuticals, agrochemicals, and liquid crystal materials due to its unique electronic properties and metabolic stability imparted by the three equivalent fluorine atoms.
Specifications
| Molecular Formula | C6H3F3 |
|---|---|
| Molecular Weight | 132.08 g/mol |
| Density | 1.277 g/cm³ |
| Melting Point | −5.5°C |
| Boiling Point | 75–76°C |
| Flash Point | 19°F (−7°C) |
| Refractive Index | 1.414 |
| Appearance | Colorless transparent liquid |
| Assay | ≥99.0% |
| Moisture | ≤0.2% |
Industrial Applications
This fluorinated benzene derivative is primarily employed as a specialty intermediate in multi-step organic syntheses. Its symmetric structure and strong electron-withdrawing character make it ideal for constructing complex molecules requiring enhanced lipophilicity, thermal stability, or resistance to oxidative metabolism. Key application areas include:
- Pharmaceutical R&D: Building block for CNS agents, kinase inhibitors, and other bioactive scaffolds.
- Liquid Crystal Synthesis: Core component in the production of fluorinated mesogens for high-performance displays.
- Agrochemical Innovation: Intermediate for next-generation herbicides and fungicides.
- Advanced Materials: Precursor for fluorinated polymers and electronic chemicals.
Stored in a cool, well-ventilated area away from ignition sources, 1,3,5-trifluorobenzene is typically supplied in 200 kg drums or customized packaging to meet global regulatory and logistical requirements.
