1,3-Difluoro-5-nitrobenzene
- CAS No.2265-94-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1,3-Difluoro-5-nitrobenzene (CAS 2265-94-3) designed for advanced organic synthesis. Reliable supply with strict quality control for pharmaceutical and agrochemical applications.
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Product Overview
1,3-Difluoro-5-nitrobenzene is a highly specialized fluorinated aromatic compound that serves as a critical building block in modern organic synthesis. As a key intermediate, this chemical features a unique substitution pattern that enables versatile functionalization through nucleophilic aromatic substitution reactions. The presence of fluorine atoms enhances metabolic stability and lipophilicity in downstream pharmaceutical candidates, making it an invaluable asset for medicinal chemistry research and development.
Our manufacturing facility produces this compound under stringent quality management systems to ensure consistent batch-to-batch reliability. We understand the precise requirements of fine chemical synthesis, where impurity profiles can significantly impact reaction yields and final product quality. Therefore, every production run undergoes rigorous analytical testing to confirm identity and purity levels before release.
Technical Specifications
The physical and chemical properties of 1,3-Difluoro-5-nitrobenzene are optimized for industrial handling and processing. The material is supplied as a light yellow liquid with high assay purity, minimizing the need for extensive purification steps prior to use. Below are the detailed technical parameters that define our standard commercial grade product.
| Parameter | Specification |
|---|---|
| CAS Number | 2265-94-3 |
| Molecular Formula | C6H3F2NO2 |
| Molecular Weight | 159.09 g/mol |
| Appearance | Light yellow liquid |
| Assay (Purity) | ≥99.0% |
| Moisture Content | ≤0.2% |
| Density | 1.407 g/cm3 |
| Melting Point | 17°C |
| Boiling Point | 176-177°C |
| Refractive Index | 1.499 |
Industrial Applications
This fluorinated nitrobenzene derivative is primarily utilized as a precursor in the synthesis of complex pharmaceutical agents and agrochemical active ingredients. The nitro group can be selectively reduced to an amine, providing a versatile handle for further derivatization into heterocycles or biaryl structures. Common application areas include the development of kinase inhibitors, anti-inflammatory drugs, and crop protection agents.
- Pharmaceutical Intermediate: Used in the construction of fluorinated drug scaffolds.
- Agrochemical Synthesis: Serves as a building block for herbicides and fungicides.
- Material Science: Employed in the production of specialized polymers and liquid crystals.
- Research and Development: Essential reagent for organic chemistry laboratories.
Storage and Handling
To maintain product integrity and ensure safety, proper storage conditions must be observed. The material should be kept in a cool, ventilated warehouse away from direct sunlight and heat sources. Containers must remain tightly closed when not in use to prevent moisture absorption and contamination. We recommend using appropriate personal protective equipment during handling, including chemical-resistant gloves and safety goggles. Our packaging options include 25 kg drums, with custom packaging available upon request to suit specific logistical requirements. Global shipping is supported with comprehensive documentation, including Certificates of Analysis and safety data sheets.
