1,3-Difluoro-5-(trifluoromethyl)benzene
- CAS No.401-85-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1,3-Difluoro-5-(trifluoromethyl)benzene (CAS 401-85-4) designed for advanced pharmaceutical synthesis. Reliable supply with ≥98.0% purity for global R&D and production needs.
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Product Overview
1,3-Difluoro-5-(trifluoromethyl)benzene represents a cornerstone molecule in modern organic synthesis and medicinal chemistry. As a highly specialized fluorinated aromatic compound, this intermediate plays a critical role in the development of novel pharmaceutical agents and agrochemical formulations. The strategic placement of fluorine atoms within the benzene ring structure significantly enhances metabolic stability and bioavailability in downstream drug candidates. Our facility specializes in the production of this key building block, ensuring consistent quality for large-scale manufacturing and research applications.
The unique chemical properties of this trifluoromethyl-substituted benzene derivative make it an indispensable reagent for cross-coupling reactions and nucleophilic substitutions. Chemists value this compound for its ability to introduce lipophilic characteristics into complex molecular architectures without compromising structural integrity. We maintain rigorous production standards to meet the demanding specifications of global pharmaceutical companies and contract research organizations.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 1,3-Difluoro-5-(trifluoromethyl)benzene |
| CAS Number | 401-85-4 |
| Molecular Formula | C7H3F5 |
| Molecular Weight | 182.02 g/mol |
| Purity | ≥98.0% |
| Appearance | Solid |
| Density | 1.386 g/cm3 |
| Boiling Point | 95.6°C at 760 mmHg |
| Flash Point | 20.5°C |
| Refractive Index | 1.391 |
Industrial Applications
This fluorinated intermediate is primarily utilized as a critical building block in the synthesis of active pharmaceutical ingredients (APIs). Its structural features allow for versatile functionalization, making it suitable for creating kinase inhibitors, receptor modulators, and other therapeutic classes. Beyond pharmaceuticals, the compound finds application in the agrochemical sector for developing advanced pesticides and herbicides with improved environmental profiles.
Researchers leverage this material for structure-activity relationship (SAR) studies where fluorine scanning is required to optimize lead compounds. The high purity grade we supply ensures minimal side reactions during sensitive catalytic processes. Our clients rely on this consistency to accelerate their development timelines and reduce purification burdens during scale-up phases.
Quality Assurance and Storage
Quality control is paramount in our manufacturing process. Every batch undergoes comprehensive analysis using high-performance liquid chromatography (HPLC) and gas chromatography (GC) to verify purity levels and identify impurities. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production facilities adhere to strict safety and environmental regulations to ensure sustainable operations.
For optimal stability, store this product in tightly closed containers at room temperature away from direct sunlight and moisture. The compound remains stable under normal storage and handling conditions. We recommend following standard laboratory safety protocols when handling fluorinated aromatics, including the use of appropriate personal protective equipment. Bulk packaging options are available to suit specific logistical requirements, ensuring safe transport to destinations worldwide.
