1,4,7,10-Tetraazacyclododecane Tetrahydrochloride
- CAS No.10045-25-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
Premium grade 1,4,7,10-Tetraazacyclododecane Tetrahydrochloride designed for MRI contrast agent synthesis. Available in bulk with full documentation.
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Product Overview
1,4,7,10-Tetraazacyclododecane Tetrahydrochloride, commonly known as Cyclen 4HCl, is a high-performance macrocyclic ligand essential in modern pharmaceutical synthesis. This compound serves as a critical building block for the production of advanced gadolinium-based contrast agents used in magnetic resonance imaging (MRI). Our manufacturing process ensures exceptional purity and structural integrity, making it the preferred choice for pharmaceutical companies developing diagnostic imaging solutions.
As a tetrahydrochloride salt, this molecule offers enhanced stability and solubility profiles compared to its free base form. This characteristic is vital for downstream reactions where precise stoichiometry and reaction kinetics are required. We specialize in supplying this intermediate to global markets with a focus on consistency, regulatory compliance, and technical support.
Technical Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 1,4,7,10-Tetraazacyclododecane Tetrahydrochloride |
| CAS Number | 10045-25-7 |
| Molecular Formula | C8H24Cl4N4 |
| Molecular Weight | 318.12 g/mol |
| Appearance | White to yellow low melting solid |
| Purity | ≥99.0% |
| Moisture Content | <0.1% |
| Melting Point | 297-300 °C |
Quality Assurance
Quality is the cornerstone of our production philosophy. Every batch of 1,4,7,10-Tetraazacyclododecane Tetrahydrochloride undergoes rigorous testing using high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. These analytical methods confirm the identity and purity of the compound, ensuring it meets the stringent requirements of pharmaceutical applications. We provide a comprehensive Certificate of Analysis (COA) with every shipment, detailing all test results and batch-specific data.
Our facility adheres to strict quality management systems, ensuring that contamination risks are minimized throughout the manufacturing and packaging processes. This commitment to quality allows our clients to streamline their own regulatory filings and production schedules without concern for raw material variability.
Industrial Applications
The primary application of this chemical intermediate is in the synthesis of Gadobutrol and related gadolinium chelates. These complexes are widely used as contrast media in MRI scans to enhance image clarity and diagnostic accuracy. The macrocyclic structure of Cyclen provides superior thermodynamic stability when complexed with gadolinium ions, reducing the risk of metal ion release in biological systems.
Beyond MRI agents, this tetraazacyclododecane derivative finds utility in research and development for novel chelating therapies and radiopharmaceuticals. Its versatile reactivity allows chemists to functionalize the nitrogen atoms for targeted drug delivery systems. We support both large-scale commercial production and smaller research-scale requirements.
Storage and Handling
To maintain optimal quality, 1,4,7,10-Tetraazacyclododecane Tetrahydrochloride should be stored in a cool, dry, and well-ventilated area. The product must be kept in tightly closed containers to protect against moisture absorption and exposure to strong light or heat sources. Proper handling procedures, including the use of personal protective equipment (PPE), are recommended during transfer and weighing operations to ensure safety.
We offer flexible packaging options, including 25kg cardboard drums or custom configurations based on customer specifications. Our logistics team ensures secure global shipping with appropriate documentation for hazardous materials where applicable. Partner with us for a reliable supply chain of critical pharmaceutical intermediates.
