Intermediates

1,4-Bis(trifluoromethyl)benzene

  • CAS No.433-19-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 1,4-Bis(trifluoromethyl)benzene (CAS 433-19-2) for pharmaceutical and pesticide synthesis. Reliable supply with strict QC.

Request Bulk Pricing

Product Technical Details

Product Overview

1,4-Bis(trifluoromethyl)benzene, also known as α,α,α,α,α,α-Hexafluoro-p-xylene, is a critical fluorinated aromatic compound widely utilized in advanced organic synthesis. As a key building block, this substance serves as an essential intermediate in the development of pharmaceutical agents and agrochemical formulations. Our manufacturing process ensures exceptional stability and reactivity, making it an ideal choice for complex chemical transformations requiring robust fluorinated structures.

The compound features a benzene ring substituted with two trifluoromethyl groups at the para positions, imparting unique electronic and steric properties. These characteristics enhance the lipophilicity and metabolic stability of downstream molecules, which is particularly valuable in medicinal chemistry programs aimed at optimizing drug candidates. We supply this material with rigorous quality control to meet the demanding standards of global research and production facilities.

Key Specifications

Our production facility adheres to strict international standards to guarantee consistency across batches. The following table outlines the typical physical and chemical properties along with our quality assurance metrics. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) to verify compliance with specified parameters.

ParameterSpecification
CAS Number433-19-2
Molecular FormulaC8H4F6
Molecular Weight214.108
AppearanceColorless transparent liquid
Purity (GC)≥99.5%
Moisture Content≤0.1%
Boiling Point116.0 ± 0.0 °C at 760 mmHg
Density1.4 ± 0.1 g/cm3

Industrial Applications

This fluorinated benzene derivative is primarily employed as a versatile intermediate in the synthesis of high-value chemicals. Its applications span across multiple sectors, including pharmaceuticals, pesticides, and specialty materials. The strong carbon-fluorine bonds provide thermal stability and resistance to oxidative degradation, which are crucial for harsh reaction conditions.

  • Pharmaceutical Intermediates: Used in the construction of bioactive molecules requiring enhanced metabolic stability.
  • Agrochemical Synthesis: Serves as a precursor for novel pesticide formulations with improved environmental profiles.
  • Organic Fluorination: Acts as a reagent for introducing trifluoromethyl groups into complex organic frameworks.
  • Material Science: Utilized in the development of polymers and liquid crystals with specific dielectric properties.

Quality Assurance and Storage

We maintain a robust quality management system to ensure product integrity from synthesis to delivery. Every batch undergoes thorough testing using advanced analytical techniques such as Gas Chromatography (GC) and Karl Fischer titration. To preserve quality, store the container tightly closed in a cool, dry, and well-ventilated area away from incompatible substances. Proper handling procedures should be followed to ensure safety during industrial use. We offer flexible packaging options, including 25kg drums, tailored to meet specific customer logistics requirements.