Intermediates

1-(4-Methoxyphenyl)piperazine Dihydrochloride

  • CAS No.38869-47-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 1-(4-Methoxyphenyl)piperazine Dihydrochloride serves as a critical pharmaceutical intermediate for Ketoconazole synthesis. We offer bulk supply with verified COA and strict quality control.

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Product Technical Details

Product Overview

1-(4-Methoxyphenyl)piperazine Dihydrochloride is a specialized organic compound widely recognized in the pharmaceutical industry for its pivotal role in synthetic chemistry. As a key building block, this substance is primarily utilized in the manufacturing of advanced antifungal medications, most notably serving as an essential intermediate in the production of Ketoconazole. Our facility ensures that every batch meets rigorous international standards for purity and consistency, supporting global pharmaceutical supply chains with reliable material sourcing.

The compound is characterized by its stable chemical structure and high reactivity under controlled conditions, making it ideal for complex organic synthesis routes. We prioritize safety and quality throughout the manufacturing process, adhering to strict Good Manufacturing Practices (GMP) to guarantee that the final product is free from contaminants and suitable for downstream pharmaceutical applications.

Technical Specifications

ParameterSpecification
Chemical Name1-(4-Methoxyphenyl)piperazine Dihydrochloride
CAS Number38869-47-5
Molecular FormulaC11H18Cl2N2O
Molecular Weight265.18 g/mol
AppearanceWhite crystalline powder
Purity≥98.0%
Moisture Content≤1.0%
Melting Point240 °C (dec.)
Boiling Point344 °C at 760 mmHg

Industrial Applications

The primary application of this chemical lies within the pharmaceutical sector, specifically as a precursor in the synthesis of Ketoconazole, a broad-spectrum antifungal agent. Its unique structural properties allow for efficient coupling reactions necessary for constructing the final active pharmaceutical ingredient (API). Beyond antifungal medications, piperazine derivatives are increasingly explored in various therapeutic areas, including neurological therapeutics and advanced organic synthesis projects.

For research and development teams, this material serves as a reliable reference standard or a starting material for developing new analogues. Our production capabilities support both large-scale commercial manufacturing and smaller batch requirements for clinical trial material synthesis, ensuring flexibility for partners at different stages of drug development.

Quality Assurance and Storage

Quality is the cornerstone of our operation. Each production lot undergoes comprehensive testing using high-performance liquid chromatography (HPLC) and other analytical methods to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment, detailing all critical quality attributes. We maintain a robust quality management system to trace every batch from raw material intake to final dispatch.

Proper storage is essential to maintain the integrity of the product. The material should be stored in a cool, dry, and well-ventilated area, kept in tightly closed containers to prevent moisture absorption. Protection from strong light and heat sources is recommended to prevent degradation. When handled according to safety guidelines, this compound remains stable over extended periods, ensuring consistent performance in your manufacturing processes.

Packaging and Logistics

We offer flexible packaging solutions to meet diverse logistical needs. Standard packaging includes 25kg cardboard drums, which are designed for safe transport and easy handling in industrial settings. Custom packaging configurations are available upon request to align with specific customer requirements or regulatory constraints in different regions. Our logistics partners ensure timely global delivery with full documentation support for customs clearance.